{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:45:41Z","timestamp":1784735141727,"version":"3.55.0"},"reference-count":53,"publisher":"S. Karger AG","issue":"11-12","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Kisspeptin (KP) is a key player in the regulation of the release of gonadotropin-releasing hormone (GnRH), which increases the secretion of gonadotropin during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. Premature activation of GnRH secretion leads to idiopathic\/central gonadotropin-dependent precocious puberty (CPP). We aimed to compare the blood KP concentrations in girls with CPP and healthy controls. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A systematic review and meta-analysis was performed. We searched MEDLINE, EMBASE, The Cochrane Library, and SciELO. Random-effects model and standardized mean difference (SMD) were used. Heterogeneity was assessed through &lt;i&gt;I&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt;. Meta-regression considered patient age, KP fraction, and analytical method for KP measurement. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The 11 studies included comprised 316 CPP patients and 251 controls. Higher KP levels in the CPP group were found (SMD 1.53; CI 95% = 0.56\u20132.51). Subgroup analysis revealed association with patient age (&lt;i&gt;p&lt;\/i&gt; = 0.048), indicating a positive correlation between elevation in KP concentration and age in CPP group. A group of patients with precocious thelarche (PT) from 5 of the included studies comprising 121 patients showed higher levels of KP (1.10; \u22120.25\u20132.45: CI 95%) and high heterogeneity (&lt;i&gt;I&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt; = 91%). The CPP\/PT ratio for KP level indicates KP 36% higher on CPP than PT patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A consistent difference in KP levels between girls with CPP and controls was identified. While there are important limitations in KP assays which argue against its use as a diagnostic tool, the KP levels in CPP versus control and PT children are consistent with the predicted mechanisms and pathophysiology of CPP. <\/jats:p>","DOI":"10.1159\/000515660","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T21:00:58Z","timestamp":1619125258000},"page":"589-598","source":"Crossref","is-referenced-by-count":18,"title":["Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"93","author":[{"given":"Rafael Guerra","family":"Cintra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Wajnsztejn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila 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