{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:07Z","timestamp":1745468887788,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Chronic kidney disease (CKD) patients infected with COVID-19 are at risk of serious complications such as hospitalization and death. The prognosis and lethality of COVID-19 infection in patients with established kidney disease has not been widely studied. <b><i>Methods:<\/i><\/b> Data included patients who underwent kidney biopsy at the Vall d\u2019Hebron Hospital between January 2013 and February 2020 with COVID-19 diagnosis during the period from March 1 to May 15, 2020. <b><i>Results:<\/i><\/b> Thirty-nine (7%) patients were diagnosed with COVID-19 infection. Mean age was 63 \u00b1 15 years and 48.7% were male. Hypertension was present in 79.5%, CKD without renal replacement therapy in 76.9%, and cardiovascular disease in 64.1%. Nasopharyngeal swab was performed in 26 patients; older (<i>p<\/i> = 0.01), hypertensive (<i>p<\/i> = 0.005), and immunosuppressed (<i>p<\/i> = 0.01) patients, those using RAS-blocking drugs (<i>p<\/i> = 0.04), and those with gastrointestinal symptoms (<i>p<\/i> = 0.02) were more likely to be tested for CO\u00adVID-19. Twenty-two patients required hospitalization and 15.4% died. In bivariate analysis, mortality was associated with older age (<i>p<\/i> = 0.03), cardiovascular disease (<i>p<\/i> = 0.05), chronic obstructive pulmonary disease (<i>p<\/i> = 0.05), and low hemoglobin levels (<i>p<\/i> = 0.006). Adjusted Cox regression showed that low hemoglobin levels at admission had 1.81 greater risk of mortality. <b><i>Conclusions:<\/i><\/b> Patients with CO\u00adVID-19 infection and kidney disease confirmed by kidney biopsy presented a mortality of 15.4%. Swab test for COVID-19 was more likely to be performed in older, hypertensive, and immunosuppressed patients, those using RAS-blocking drugs, and those with gastrointestinal symptoms. Low hemoglobin is a risk factor for mortality. <\/jats:p>","DOI":"10.1159\/000515714","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T21:00:53Z","timestamp":1623099653000},"page":"452-459","source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease"],"prefix":"10.1159","volume":"46","author":[{"given":"Juan Le\u00f3n","family":"Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Garc\u00eda-Carro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Agraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nestor","family":"Toapanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ander","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Gabald\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Bury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia","family":"Baldallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ser\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2009249"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02451-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2011400"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.031"},{"key":"ref7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2011117"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3539"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.03.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008975"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03530320"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30854-0"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:29Z","timestamp":1745426249000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,20]]},"published-print":{"date-parts":[[2021,8,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000515714","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14743197","asserted-by":"subject"}]},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2021]]}}}