{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:33Z","timestamp":1792804173666,"version":"4.5.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficient treatment of primary dystonia. Few studies have reported the effect of STN-DBS on secondary or acquired dystonia. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We reported 2 patients with acquired dystonia treated by subthalamic DBS and followed up for 24 months, besides providing a systematic review and meta-analysis of published series. &lt;b&gt;&lt;i&gt;Results\/Conclusions:&lt;\/i&gt;&lt;\/b&gt; Both patients had thalamic vascular or autoimmune lesions within the ventral and the pulvinar nuclei. A reduction of 67.2% on the Burke-Fahn-Marsden Dystonia Rating Scale and 90% improvement in disability scores were shown in the first patient, while the second patient showed a lower reduction in both dystonia symptoms (28.6%) and disability scores (44%). Both patients had a significant mean improvement in the quality of life (62.5% in the first and 57.9% in the second) and were free of drugs postoperatively. A systematic review showed a mean follow-up of 13 months in 19 patients, including our 2 patients. The review showed a significant Burke-Fahn-Marsden Dystonia Scale (BFMDRS) score median reduction of 19 points (52.4%; confidence interval [CI]: 11.0\u201325.0) and a significant median reduction of 6 points in disability scores (44.5%; 95% CI: 4.0\u201314.0), thereby improving quality of life. Age at surgery was inversely correlated with postoperative improvement (&lt;i&gt;r&lt;\/i&gt; = 0.63; &lt;i&gt;p&lt;\/i&gt; = 0.039). Hemidystonia had a nonsignificant better improvement than generalized dystonia (55.3 vs. 43.5%; &lt;i&gt;p&lt;\/i&gt; = 0.4433). No association between etiology and postoperative improvement and no serious complications were found. Although few data reported so far, subthalamic DBS is likely efficient for acquired dystonia. <\/jats:p>","DOI":"10.1159\/000515723","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T21:01:40Z","timestamp":1620334900000},"page":"412-424","source":"Crossref","is-referenced-by-count":4,"title":["Subthalamic Nucleus Deep Brain Stimulation Lessens Acquired Dystonia: Report of Two Patients and Systematic Review of Published Cases"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-3994","authenticated-orcid":false,"given":"Maria Sheila","family":"Guimar\u00e3es Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Let\u00edcia de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iara Amorim","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Camila","family":"Alves Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Terzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Fellipe","family":"Santos Tatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Godinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.2547510.1002\/mds.25475"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21029.2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.147828810.1080\/14737175.2018.1478288"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-1047-910.1007\/s10143-018-1047-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.10875010.1016\/j.jneumeth.2020.108750"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820f2e4f10.1212\/WNL.0b013e31820f2e4f"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2017.04.12310.1016\/j.brs.2017.04.123"},{"key":"ref8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.35.1.7310.1212\/wnl.35.1.73"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6846.160"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b253510.1136\/bmj.305.6846.160"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200605010-00017"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3171\/2013.7.PEDS1350"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.12.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2017.04.123"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13145"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-019-02010-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.05.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200612020-00008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70151-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53497-2.00014-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.207993"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.5110.1001\/jamaneurol.2015.51"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53497-2.00014-0"},{"key":"ref25"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3171\/2018.12.jns18192710.1016\/B978-0-444-53497-2.00014-0"},{"key":"ref27"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/mds.2805710.1016\/j.parkreldis.2013.12.012"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.01710.1016\/j.parkreldis.2018.04.017"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.20180957510.15252\/emmm.201809575"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:33Z","timestamp":1745426253000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,8,31]]},"published-print":{"date-parts":[[2021,9,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000515723","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14545800","asserted-by":"subject"}]},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}