{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:53:55Z","timestamp":1756385635187,"version":"3.40.5"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Idiopathic CD4&lt;sup&gt;+&lt;\/sup&gt; lymphocytopenia (ICL) is the depletion of CD4&lt;sup&gt;+&lt;\/sup&gt; lymphocytes to &amp;#x3c;300 cells\/mm&lt;sup&gt;3&lt;\/sup&gt; without human immunodeficiency virus infection or other causes of lymphocytopenia. ICL causes fatal infections; its etiology remains unclear and it lacks consensus regarding therapeutic options. We report the first patient with ICL who had a successful clinical course following a cord blood transplant (CBT). A 45-year-old woman was diagnosed with ICL and underwent partial hepatectomy for an abscess caused by the &lt;i&gt;Mycobacterium avium&lt;\/i&gt; complex. No specific gene alterations were detected through next generation sequencing-based evaluation. Following a reduced-intensity conditioning (RIC) regimen consisting of fludarabine, busulfan, and 4 Gy total body irradiation, a single-unit CBT was performed. Neutrophils were engrafted on day +14. CD4&lt;sup&gt;+&lt;\/sup&gt; lymphocyte counts increased to over 300 cells\/mm&lt;sup&gt;3&lt;\/sup&gt; on day +436. After 75 months, she was alive without any sequelae. CBT with an RIC regimen could be a curable treatment option for ICL. <\/jats:p>","DOI":"10.1159\/000516347","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:17:09Z","timestamp":1622582229000},"page":"698-705","source":"Crossref","is-referenced-by-count":1,"title":["Successful Cord Blood Transplantation for Idiopathic CD4&lt;sup&gt;+&lt;\/sup&gt; Lymphocytopenia"],"prefix":"10.1159","volume":"144","author":[{"given":"Keita","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-0021","authenticated-orcid":false,"given":"Yuho","family":"Najima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Sadato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Inamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Mukae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Shingai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Toya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Kakihana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuteru","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-3179","authenticated-orcid":false,"given":"Noriko","family":"Doki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280604"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0770.114121"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S214139"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.07.021"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127878"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280602"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055570"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1806"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01619.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12086"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08735.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26048"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12160"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19069"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0535-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00755.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-598565"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02166.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0458-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00239"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00445"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0960"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm12064362"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24613"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.116"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00362"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.134.1.83"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