{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:17:56Z","timestamp":1778228276160,"version":"3.51.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Central precocious puberty (CPP) in females is characterized by thelarche before 8 years of age. Evidence of reproductive axis activation confirms the diagnosis (basal serum luteinizing hormone (LH) \u22650.3 IU\/L or LH-releasing hormone (LHRH)-stimulated LH \u22655 IU\/L). Stimulation testing is the diagnostic gold standard but is time-consuming and costly. Serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) are increased in girls with CPP. <b><i>Objective:<\/i><\/b> The aim of the study was to assess the utility of serum IGF-1 and IGFBP-3 in identifying CPP in girls aged 6\u20138 years. <b><i>Methods:<\/i><\/b> The study was a single-center retrospective study. Girls with confirmed CPP (<i>n<\/i> = 44) and isolated premature precocious adrenarche\/ precocious thelarche (PA\/PT, <i>n<\/i> = 16) had baseline biochemical profiling and LHRH stimulation testing. Serum IGF-1 and IGFBP-3 results were converted to standard deviation scores (SDS). Correlations were calculated and receiver operating characteristic curves were plotted. <b><i>Results:<\/i><\/b> Girls with CPP had higher basal and peak LH, IGF-1 SDS, and growth velocity (<i>p<\/i> &#x3c; 0.05). IGF-1 SDS correlated positively with basal and peak LH (<i>p<\/i> &#x3c; 0.05). IGF-1 SDS (1.75\u20132.15) differentiated CPP and PA\/PT with 89% sensitivity and 56% specificity (basal LH) and 94% specificity and 55% sensitivity (peak LH). IGFBP-3 SDS did not differ between groups or by CPP parameters. <b><i>Conclusions:<\/i><\/b> In clinical practice, IGF-1 SDS may be an additional tool for identifying CPP in girls aged 6 to 8 years when baseline clinical and laboratory diagnostic criteria are inconclusive, possibly avoiding more time-consuming and costly procedures. <\/jats:p>","DOI":"10.1159\/000516361","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T21:00:53Z","timestamp":1623099653000},"page":"44-51","source":"Crossref","is-referenced-by-count":13,"title":["Insulin-like Growth Factor 1, but Not Insulin-Like Growth Factor-Binding Protein 3, Predicts Central Precocious Puberty in Girls 6\u20138 Years Old: A Retrospective Study"],"prefix":"10.1159","volume":"94","author":[{"given":"Patricia Diaz","family":"Escagedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheri L.","family":"Deal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-8730","authenticated-orcid":false,"given":"Michael","family":"Hauschild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.2.116"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0627-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000164"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02960.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0106"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-1-152"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00213"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1180"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2745"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13633-016-0027-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02151"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000491103"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.109201"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.112"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.8.7543116"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.78.3.8126152"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1999.12.2.139"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0019"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00923.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.10.7559897"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:55:01Z","timestamp":1745420101000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000516361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":23,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2021,7,20]]},"published-print":{"date-parts":[[2021,9,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000516361","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}