{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:22:36Z","timestamp":1745468556687,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Oncogenic osteomalacia (Onc-Ost) is a paraneoplastic phenomenon characterized by hypophosphatemia due to elevated fibroblast growth factor-23 (FGF-23). Onc-Ost has been previously reported in patients with germ line mesenchymal tumors and solid organ malignancies. This is the first report of aggressive natural killer (NK) T-cell lymphoma presenting as Onc-Ost. &lt;b&gt;&lt;i&gt;Case Description:&lt;\/i&gt;&lt;\/b&gt; A 33-year-old Vietnamese female with active hepatitis B and &lt;i&gt;Mycobacterium avium&lt;\/i&gt; complex, on ongoing therapy with tenofovir disoproxil, azithromycin, and ethambutol, presented with persistent fevers and developed refractory hypophosphatemia. Workup confirmed severe renal phosphate wasting. Tenofovir disoproxil was initially suspected; however, presence of isolated phosphaturia without Fanconi syndrome and persistence of hypophosphatemia despite discontinuation of medication led to clinical suspicion of Onc-Ost. Elevated FGF-23 warranted further workup, leading to a definitive diagnosis of clinically subtle NK T-cell lymphoma. Chemotherapy was initiated; however, patient continued to deteriorate clinically and expired. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Along with commonly reported germ line mesenchymal tumors and solid malignancies, NK T-cell lymphoma can also present as Onc-Ost. Timely detection of associated tumors and subsequent antitumor therapy would likely reverse hypophosphatemia and improve clinical outcomes. <\/jats:p>","DOI":"10.1159\/000516390","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T21:01:05Z","timestamp":1626987665000},"page":"647-651","source":"Crossref","is-referenced-by-count":5,"title":["A Case of Hypophosphatemia due to Oncogenic Osteomalacia in a Patient with Natural Killer T-Cell Lymphoma"],"prefix":"10.1159","volume":"46","author":[{"given":"Guoliang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetha Rani","family":"Kanduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Canterbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos Q.","family":"Velez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1507\/endocrj.EJ16-0587"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1177\/1066896915617828"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1210\/jc.2014-2120"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1136\/bcr-2015-213954"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1056\/NEJMcps1305773"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016\/j.biopha.2017.11.037"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1530\/EJE-09-0597"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1681\/ASN.2007010068"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1210\/jcem-67-1-46"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1001\/jama.294.10.1260"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.3760\/cma.j.issn.1673-0860.2019.08.012"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.12998\/wjcc.v7.i15.2081"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1002\/jbmr.1881"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1002\/lt.500060326"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016\/j.clinimag.2019.04.007"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1210\/jcem.85.2.6368"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.2215\/CJN.15201218"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:55:12Z","timestamp":1745420112000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000516390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000516390","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2021]]}}}