{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:36:29Z","timestamp":1791041789376,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The degree to which a family history of coronary heart disease (FHCHD) is associated with silent cerebral small-vessel disease (cSVD) among healthy adults, independent of prevalent CHD and traditional risk factors, is unknown. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The Atherosclerosis Risk in Communities (ARIC) study is a community-based cohort study with self-reported family history data and brain magnetic resonance imaging (ages 68\u201388). The association between markers of cSVD (lacunar infarcts and cerebral microbleeds), or log-transformed white matter hyperintensity (WMH) volume, and FHCHD, or the number of affected relatives was examined using separate adjusted logistic or linear regression models, respectively. Race interaction terms were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 1,639 participants without prevalent CHD (76 \u00b1 5 years, 62% female, 29% black), 686 (42%) had FHCHD. There were higher odds of lacunar infarct (OR 1.40, 95% CI 1.07\u20131.84) among those with parental FHCHD and higher odds of microhemorrhages (lobar OR 1.86, 95% CI 1.13\u20133.06; subcortical OR 1.47, 95% CI 1.01\u20132.15) among those with sibling FHCHD. A greater number of any relative affected was associated with higher odds of lacunar infarct (OR 1.24, 95% CI 1.04\u20131.47) and lobar microhemorrhages (OR 1.31, 95% CI 1.05\u20131.64) but not subcortical microhemorrhages (OR 1.09, 95% CI 0.92\u20131.28). Odds of having a lacunar infarct were higher among blacks (p-interaction 0.04) with paternal FHCHD (OR 2.20, CI 1.35\u20133.58) than whites with paternal FHCHD (OR 1.17, CI 0.87\u20131.56). There was no association with WMH. &lt;b&gt;&lt;i&gt;Discussion\/Conclusion:&lt;\/i&gt;&lt;\/b&gt; Markers of cSVD, specifically lacunar infarcts and microhemorrhages, appear to be associated with FHCHD, potentially representing shared mechanisms in different vascular beds, and perhaps a genetic propensity for vascular disease. <\/jats:p>","DOI":"10.1159\/000516428","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T21:00:32Z","timestamp":1623963632000},"page":"316-322","source":"Crossref","is-referenced-by-count":5,"title":["Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study"],"prefix":"10.1159","volume":"55","author":[{"given":"Michelle C.","family":"Johansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Nyquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.61.3.503"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.06.031"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2012.094"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000980"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19111-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000858"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.01.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001557"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000480238"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007847"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00041-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.10.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.12.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(90)90216-k"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/hc2901.093115"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-3797(02)00587-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003186"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000222012.56447.00"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0933-z"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5414\/cpp38075"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.176"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.9.2098"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000199847.96188.12"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.501650"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:55:40Z","timestamp":1745420140000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000516428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,16]]},"published-print":{"date-parts":[[2021,9,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000516428","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}