{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:27:55Z","timestamp":1779362875961,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background and Aim:<\/i><\/b> The aim of this study was to identify the utility of <sup>18<\/sup>F-fluorodeoxyglucose positron emission tomography\/computed tomography (<sup>18<\/sup>F-FDG-PET\/CT) as a predictor of overall prognosis in patients with hepatocellular carcinoma treated with lenvatinib. <b><i>Methods:<\/i><\/b> Forty-eight consecutive patients who received lenvatinib treatment were reviewed. The oncological aggressiveness of tumors estimated using <sup>18<\/sup>F-FDG-PET\/CT was investigated by the analysis of progression-free survival (PFS), post-progression survival (PPS), and overall survival (OS). Multivariate analysis was used to identify potential confounders for OS during lenvatinib therapy. <b><i>Results:<\/i><\/b> Using the Modified Response Evaluation Criteria in Solid Tumors, a tumor-to-normal liver ratio (TLR) \u22652, indicating higher oncological aggressiveness in HCCs, was associated with a better objective response to lenvatinib than a TLR &#x3c;2 (78 vs. 62%), resulting in a similar PFS (<i>p<\/i> = 0.751). Because of a significantly worse PPS, OS with a TLR \u22652 was poor compared to a TLR &#x3c; 2 (<i>p<\/i> = 0.012). Multivariate analysis confirmed that a TLR \u2265 2 was associated with poor OS (hazard ratio, 2.709; 95% CI, 1.140\u20136.436; <i>p<\/i> = 0.024). Analysis of 24 patients who received a repeat <sup>18<\/sup>F-FDG-PET\/CT showed that daily changes expressed as \u0394TLR \u00d7 10<sup>3<\/sup>\/day over the treatment course tended to be different among the types of subsequent treatment. A R0 resection and lenvatinib-TACE sequential therapy provided good disease control (median, \u22124.593 and \u22120.024, respectively) compared with other treatments (median, 5.278) (<i>p<\/i> = 0.075). <b><i>Conclusion:<\/i><\/b> Lenvatinib has acceptable disease control regardless of estimated tumor differentiation. A high TLR (\u22652) is a poor prognostic factor of OS following lenvatinib treatment, while \u0394TLR \u00d7 10<sup>3<\/sup>\/day provides useful information of disease control status. <\/jats:p>","DOI":"10.1159\/000516565","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T21:00:32Z","timestamp":1623963632000},"page":"611-621","source":"Crossref","is-referenced-by-count":4,"title":["Pretreatment Positron Emission Tomography with <sup>18<\/sup>F-Fluorodeoxyglucose May Be a Useful New Predictor of Overall Prognosis Following Lenvatinib Treatment"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-0042","authenticated-orcid":false,"given":"Yusuke","family":"Kawamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Shindoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Muraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Iritani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Fujiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-2275","authenticated-orcid":false,"given":"Tetsuya","family":"Hosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Akuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-5552","authenticated-orcid":false,"given":"Yoshiyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuji","family":"Arase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-3348","authenticated-orcid":false,"given":"Masaji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1263-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000507370"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000505190"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1357"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1990-y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2366-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3871-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0791-5"},{"key":"ref10"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000368142"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3348-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6672-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081084"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000510299"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041076"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:56:51Z","timestamp":1745420211000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000516565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,9,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000516565","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-24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