{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:16Z","timestamp":1787017936782,"version":"build-2736575974"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Caregivers of patients with early-onset dementia (EOD) experience high levels of burden, which is known to be affected by caregivers\u2019 psychological features as well as by patients\u2019 and caregivers\u2019 demographical and social variables. Although potential clinical, demographical, and social determinants have been separately examined, it is not known how they reciprocally interact. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Ninety-two consecutive patient-caregiver dyads were recruited from the Cognitive Neurology Clinics of Modena, Northern Italy. Caregivers were asked to fill in questionnaires regarding their burden, psychological distress, and family economic status. Data were analyzed with multivariable regression models and then entered in a mediation model. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Caregiver burden was positively related to female caregiver sex, spousal relationship to the patient, severity of patient\u2019s behavioral symptoms, diagnostic delay, and financial distress of the family. It was negatively related to disease duration, patient\u2019s education, region of birth, caregiver age, number of caregiver\u2019s days off work, number of offspring, and caregiver perception of patient\u2019s quality of life. While the effect of caregiver age, diagnostic delay, and of proxies of family or social network directly impacted on caregiver\u2019s burden, the effect of patient\u2019s disease duration, being a wife caregiver, financial distress, and number of caregiver\u2019s days off work was entirely mediated by the level of caregiver psychological distress. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Both direct actions (such as increasing social networks and shortening diagnostic delay) and indirect actions aimed at reducing psychological distress (such as increasing the number of caregiver\u2019s days off work and financial support) should be planned to reduce caregiver\u2019s burden.<\/jats:p>","DOI":"10.1159\/000516585","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T17:00:51Z","timestamp":1628874051000},"page":"189-197","source":"Crossref","is-referenced-by-count":32,"title":["Determinants of Caregiver Burden in Early-Onset Dementia"],"prefix":"10.1159","volume":"11","author":[{"given":"Annalisa","family":"Chiari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pistoresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Vinceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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