{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:04:40Z","timestamp":1753182280537,"version":"3.40.5"},"reference-count":47,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Acute liver failure (ALF) is a rare disease with potentially high mortality. We sought to assess the individual approach to ALF by intensive care unit (ICU) professionals. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Cross-sectional survey of ICU professionals. Web-based survey capturing data on respondents\u2019 demographics, characteristics of patients with ALF admitted to ICU, and their management. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 204 participants from 50 countries, 140 (68.6%) worked in Europe, 146 (71.6%) were intensivists, 142 (69.6%) admitted &amp;#x3c;25 patients with ALF per year, and 166 (81.8%) reported &amp;#x3c;25% of patients had paracetamol-related ALF. On patients\u2019 outcomes, 126 (75.0%) reported an emergency liver transplantation (ELT) rate &amp;#x3c;25% and 140 (73.3%) a hospital mortality rate &amp;#x3c;50%. The approach to ALF in the ICU varied with age, region, level of training, type of hospital, and etiology (prescribing N-acetylcysteine for paracetamol toxicity, triggers for endotracheal intubation, measurement of and strategies for lowering serum ammonia, extracorporeal device deployment, and prophylactic antibiotics). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The management of patients with ALF by ICU professionals differed substantially concerning the relevant clinical measures taken. Further education and high-quality research are warranted. <\/jats:p>","DOI":"10.1159\/000516672","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T21:00:32Z","timestamp":1621976432000},"page":"22-30","source":"Crossref","is-referenced-by-count":2,"title":["Variation in the Care of Acute Liver Failure: A Survey of Intensive Care 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