{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:33:12Z","timestamp":1747193592669,"version":"3.40.5"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Antibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin-induced autoimmune hepatitis and lung fibrosis that fulfills the definitive clinical criteria for diagnosis, presenting histological, imagiological, and immunological evidence of nitrofurantoin-induced toxicity. It occurred in a 68-year-old woman with extended nitrofurantoin intake for urinary tract infection prophylaxis who presented with progressive exercise dyspnea and jaundice. Similar published cases are also reviewed in this article. <\/jats:p>","DOI":"10.1159\/000516940","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T21:00:46Z","timestamp":1625086846000},"page":"273-279","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease"],"prefix":"10.1159","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4738-1683","authenticated-orcid":false,"given":"Andreia","family":"Carvalho\u00a0de\u00a0Matos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Pais\u00a0Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Afonso\u00a0Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Augusta","family":"Cipriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9lia","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080327"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2012.e83"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23588"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-13-39"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-3088"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/1547691X.2016.1254305"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2298\/VSP1206536M"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4212\/cjhp.v64i4.1039"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-59"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90783-U"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40536-1"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/516940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:00:09Z","timestamp":1745420409000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000516940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,6,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000516940","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"type":"print","value":"2341-4545"},{"type":"electronic","value":"2387-1954"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}