{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:35:51Z","timestamp":1793223351094,"version":"4.5.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>New kinds of HIV-1 circulating recombinant forms (CRFs) and unique recombinant forms (URFs) earn a great prevalence in China nowadays. In this study, we identified 2 similar URFs (2016GXNNIDU037 and 2019QZLSIDU253) both isolated from intravenous drug users (IDUs) in Guangxi, China. Phylogenetic analysis of the near full-length genome (NFLG) revealed 2 URFs both clustered with CRF01_AE but setting up a monophyletic branch, supporting a high bootstrap value. Bootscan analysis and subregional recombinant analysis found that the NFLG of 2016GXNNIDU037 and 2019QZLSIDU253 were both composed of CRF01_AE and CRF07_BC, with 3 CRF07_BC mosaic segments inserted into CRF01_AE backbones. The CRF01_AE segments of the 2 URFs clustered with a previously reported cluster 2 lineage of CRF01_AE. The 5 recombinant breakpoints of the 2 URFs were quite similar. Distinct from CRF01_AE\/CRF07_BC URFs reported before, 2016GXNNIDU037 and 2019QZLSIDU253 are new evidence of a high genetic variety of HIV-1 in Guangxi, which may pose new challenges to HIV-1 prevention and molecular epidemiological surveillance in China. <\/jats:p>","DOI":"10.1159\/000517052","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T21:00:35Z","timestamp":1625000435000},"page":"58-66","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Two Similar Novel HIV-1 Recombinant Forms (CRF01_AE\/CRF07_BC) among Intravenous Drug Users in Guangxi, China"],"prefix":"10.1159","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-0321","authenticated-orcid":false,"given":"Fei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112103052401"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2016.0029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00050-12"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2017.0066"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2015.0329"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.05.023"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.23.11367-11376.2000"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2019.0182"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2017.0101"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-6450.2019.05.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001070-00009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.1.151"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:01:28Z","timestamp":1745420488000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000517052","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]}}}