{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T17:28:37Z","timestamp":1749144517113,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a cross-sectional study of primary enucleated group D\/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [&lt;i&gt;Community Eye Health&lt;\/i&gt;. 2018;31(101):17\u20133]. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25\u201336 months. High-risk features (HRFs) were found in 100\/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age &amp;#x3e;2 years associated with tumor differentiation (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged &amp;#x3e;2 years old. <\/jats:p>","DOI":"10.1159\/000517100","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:00:57Z","timestamp":1626814857000},"page":"353-360","source":"Crossref","is-referenced-by-count":3,"title":["High-Risk Histopathologic Features of Retinoblastoma Treated at a Tertiary Hospital in West Java, Indonesia"],"prefix":"10.1159","volume":"7","author":[{"given":"Nur Melani","family":"Sari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Hadiputri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya Sari","family":"Kuntorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasrayati","family":"Agustina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friska","family":"Mardianty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000141"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2013.11.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-020-01342-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2015.1016241"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.99731"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.044"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2018.12.22"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20130306-02"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.62"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201870"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.048"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.289"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1043\/1543-2165-133.8.1199"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.12.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2018.3.2.37"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000477408"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4314\/ajhs.v13i1.30825"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0244-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.20473\/juxta.v10i22019.52-56"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0759-OA"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1043\/1543-2165-133.8.1210"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohc.2004.09.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.037044"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(87)33436-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.177444"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.61.6.417"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.146747"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:01:56Z","timestamp":1745420516000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,5]]},"published-print":{"date-parts":[[2021,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000517100","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2021]]}}}