{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:10:05Z","timestamp":1782738605116,"version":"3.54.5"},"reference-count":26,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to examine the effectiveness of a modified-short hydration gemcitabine and cisplatin (m-shGC) regimen for patients with metastatic urothelial carcinoma (mUC) and to assess the efficacy of a geriatric nutritional risk index (GNRI) with regard to prognosis. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; From January 2016 to July 2020, 68 patients with mUC underwent first-line m-shGC therapy with 70 mg\/m&lt;sup&gt;2&lt;\/sup&gt; cisplatin and 1,000 mg\/m&lt;sup&gt;2&lt;\/sup&gt; gemcitabine (days 1, 8, and 15), with 2,050 mL fluid replaced on the first day of each 28-day cycle. Prior to the start of treatment, the serum neutrophil-to-lymphocyte ratio (NLR), and levels of albumin and C-reactive protein (CRP) in serum, as well as body heights and weights were measured. Patients were grouped according to GNRI &amp;#x3c;92 (low) or \u226592 (high). The analysis of data was done retrospectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Median follow-up was found to be 12.9 (range 1.7\u201350.2) months and the objective response rate (ORR) was 54.4% after m-shGC treatment. The ORR was significantly different when high and low-GNRI groups were compared (ORR: 28.0 vs. 69.8% in low- vs. high-GNRI groups). Median overall survival (OS) was calculated as 8.6 (95% confidence interval [CI]: 5.4\u201321.3) and 34.5 (95% CI: 20.5\u2013NA) months for low- and high-GNRI groups, respectively (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001). Unlike for NLR and CRP, univariate and multivariate analyses revealed that low GNRI and visceral metastases were significant prognostic factors for short OS. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; First-line m-shGC showed a survival benefit for mUC, with GNRI a useful prognostic biomarker. <\/jats:p>","DOI":"10.1159\/000517326","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:00:57Z","timestamp":1626814857000},"page":"622-631","source":"Crossref","is-referenced-by-count":7,"title":["First Report of Oncological Outcome and Prognostic Analysis in a First-Line Setting of Short Hydration Gemcitabine and Cisplatin Chemotherapy for Patients with Metastatic Urothelial Carcinoma"],"prefix":"10.1159","volume":"99","author":[{"given":"Taku","family":"Naiki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Etani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Hamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyasu","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2564"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3068"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000493951"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds541"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2018-000342"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300205"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000506992"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0705-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4097-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5551\/jat.49767"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1512640"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000508923"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.106"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2016.04.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1921"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.6979"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28767"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00694330"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613683"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2411"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5534"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.09076.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys124"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(95)90001-2"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:03:46Z","timestamp":1745420626000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,9,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000517326","archive":["Portico"],"relation":{}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