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Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination. <\/jats:p>","DOI":"10.1159\/000517338","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T21:00:32Z","timestamp":1621976432000},"page":"290-298","source":"Crossref","is-referenced-by-count":11,"title":["Hyposplenism and Gastrointestinal Diseases: Significance and Mechanisms"],"prefix":"10.1159","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-5927","authenticated-orcid":false,"given":"Abhinav","family":"Mathur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mairi 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