{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:08:50Z","timestamp":1788282530137,"version":"build-2803163510"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Hyponatremia is one of the most common disorders of electrolytes. Some research studies reported that hyponatremia was closely associated with mortality in patients with dialysis. However, this viewpoint remains controversial. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We aimed to do a systematic review and meta-analysis to assess the influence of hyponatremia on mortality in patients with dialysis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We identified the eligible studies that investigated the association between hyponatremia and mortality risk in patients under dialysis by searching systematically a series of databases including PubMed, Embase, Cochrane, Web of science, and Ovid from January 2011 to June 2020. Adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) were pooled. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; From 1,116 records identified, 12 studies including prospective and retrospective cohort studies met our inclusion criteria. We found hyponatremia both at baseline (HR: 1.50 and 95% CI: 1.41\u20131.59) and in time-varying (HR: 1.63 and 95% CI: 1.44\u20131.84) were significantly correlated to all-cause mortality after multivariable adjusted. By the subgroup analysis, the same results were presented in hemodialysis (HR: 1.48 and 95% CI: 1.38\u20131.59) or peritoneal dialysis patients (HR: 1.52 and 95% CI: 1.37\u20131.70). We also observed that lower serum sodium was independently associated with cardiovascular death. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Hyponatremia was independently associated with all-cause and cardiovascular mortality, and it might predict adverse outcomes of patients under dialysis. <\/jats:p>","DOI":"10.1159\/000517340","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:00:57Z","timestamp":1626814857000},"page":"345-354","source":"Crossref","is-referenced-by-count":11,"title":["A Systematic Review and Meta-Analysis: Hyponatremia Predicted All-Cause and Cardiovascular Mortality in Dialysis Population"],"prefix":"10.1159","volume":"51","author":[{"given":"Jin\u2019e","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-3-263"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06120809"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606123142401"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.07.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.513"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1876OC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.026"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12468"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2019.02.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2016.49"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/089686080102100103"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/732746"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-113"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129480"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.945182"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4236\/oalib.1103623"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.07.029"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.07.013"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02613.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw254"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000505614"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.367"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-276"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111373"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.296"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12013"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00239"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16242-3"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:03:54Z","timestamp":1745420634000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000517340","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.15022107","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]}}}