{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:28:26Z","timestamp":1762432106554,"version":"3.40.5"},"reference-count":41,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Despite excellent biocompatibility, insertion of silicone peritoneal dialysis (PD) catheters can induce minor foreign body reaction, affecting long-term patient outcomes. We evaluated the effect of eosinophilic reaction associated with PD catheter insertion on outcomes of patients initiating PD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eosinophilic reaction to PD catheter insertion was defined as the ratio of peripheral blood eosinophil count at 1 week after insertion (E1W) to pre-insertion eosinophil count (E0), and the association of E1W\/E0 with technique survival, peritonitis-free survival, and heart failure (HF)-related hospitalization-free survival was analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This retrospective cohort study included 116 patients (89 male patients) who underwent PD catheter insertion between January 2008 and June 2018 (61.3 \u00b1 12.9 years). The follow-up duration was 46.2 (23.8\u201375.3) months. E1W was significantly higher than E0 (median, 333 vs. 234\/\u03bcL, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), with a median E1W\/E0 of 1.54. The log-rank test showed that technique survival, peritonitis-free survival, and HF-related hospitalization-free survival were significantly better in patients with E1W\/E0 &amp;#x3c; 1.54 than in those with E1W\/E0 \u2265 1.54 (&lt;i&gt;p&lt;\/i&gt; = 0.002, &amp;#x3c;0.001, and &amp;#x3c;0.001, respectively). By the Cox regression analysis adjusted for age, sex, the Charlson comorbidity index, the estimated glomerular filtration rate, and the geriatric nutritional risk index, E1W\/E0 remained a significant risk factor for technique failure, peritonitis, and hospitalization for HF (hazard ratio (HR) 1.68, &lt;i&gt;p&lt;\/i&gt; = 0.01; HR 2.19, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001; HR 2.15, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001, respectively). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Eosinophilic reaction at the time of PD catheter insertion is a novel marker that may predict outcomes in patients initiating PD. <\/jats:p>","DOI":"10.1159\/000517349","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:00:57Z","timestamp":1626814857000},"page":"355-364","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilic Reaction at the Time of Catheter Insertion Predicts Survival in Patients Initiating Peritoneal Dialysis"],"prefix":"10.1159","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-1263","authenticated-orcid":false,"given":"Kiyotaka","family":"Uchiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Washida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei","family":"Kusahana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashin","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohkichi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000093595"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340090068016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360010150023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(88)80209-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2004.19.2.121"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00794.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.00937.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2017.00205"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000045266"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.3.768"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfq080"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00087"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00074"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2008.00277"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00096"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.10.019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy340"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13604"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.181"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12726"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V75745"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102158"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp056"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13444"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36341"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00430.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120529"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01012.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.07.006"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1177\/089686080802800218"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902673"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.04.009"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000485689"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0729-0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91710-p"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-3019(97)00014-1"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.3.0536"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/all.12161"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2016.00078"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2016.00120"}],"container-title":["Blood 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