{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:35:03Z","timestamp":1784907303365,"version":"3.55.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; We investigated whether the expression of L-type amino acid transporter 1 (LAT-1) in clinical gastric cancer (GC) patients could predict patient therapeutic response to postoperative adjuvant chemotherapy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Immunohistochemistry was used to investigate LAT-1, CD98, and phosphorylated-mammalian target of rapamycin (p-mTOR) expression in 111 GC patients. To clarify whether LAT-1 influences the therapeutic effects of chemotherapy, the correlation between disease-free survival rates and LAT-1 was determined in 2 groups: 59 patients who did not undergo postoperative adjuvant chemotherapy and 52 patients who did undergo postoperative adjuvant chemotherapy. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; LAT-1 was significantly correlated with CD98 and p-mTOR expressions. We did not find any statistically significant correlation between LAT-1 and recurrence in the nontreated group. In contrast, a significant association was found between LAT-1 expression and disease-free survival in the chemotherapy group. Moreover, multivariate regression analysis demonstrated that LAT-1 was an independent predictor of disease-free survival in the postoperative adjuvant chemotherapy group (&lt;i&gt;p&lt;\/i&gt; = 0.012). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Our findings demonstrate that LAT-1 is a useful predictive marker for a successful postoperative adjuvant chemotherapy treatment. <\/jats:p>","DOI":"10.1159\/000517371","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T21:00:37Z","timestamp":1628888437000},"page":"732-739","source":"Crossref","is-referenced-by-count":9,"title":["High L-Type Amino Acid Transporter 1 Levels Are Associated with Chemotherapeutic Resistance in Gastric Cancer Patients"],"prefix":"10.1159","volume":"99","author":[{"given":"Nobuhiro","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munenori","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-7512","authenticated-orcid":false,"given":"Yasunari","family":"Ubukata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-5157","authenticated-orcid":false,"given":"Akihiko","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-3132","authenticated-orcid":false,"given":"Makoto","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Yokobori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroomi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsunari","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i29.3390"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.907337"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/26246"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23629"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2736(01)00384-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.7148"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i41.4643"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21650"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2013.05.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02151.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0041-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0457-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.12.015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.310"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s1476-5586(04)80054-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1212704"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-016-0118-y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01386.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.02.135"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02650.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.178"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11357"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13092"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13908"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:04:16Z","timestamp":1745420656000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,11,2]]}},"URL":"https:\/\/doi.org\/10.1159\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