{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:53:18Z","timestamp":1774317198639,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Background: Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. Objective: To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. Methods: This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum\/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. Results: Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = \u20139.02 ng\/mL, 95% CI = \u201313.22 to \u20134.81, p &lt; 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68\u20135.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity. Conclusion: This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne. <\/jats:p>","DOI":"10.1159\/000517514","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T21:01:26Z","timestamp":1628110886000},"page":"404-411","source":"Crossref","is-referenced-by-count":10,"title":["Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis"],"prefix":"10.1159","volume":"238","author":[{"given":"Yusuf","family":"Hasamoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunlawat","family":"Thadanipon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-7897","authenticated-orcid":false,"given":"Premjit","family":"Juntongjin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2018.024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.04.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.334"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2014.01.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.5.665"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708852"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147601"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(01)00377-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.8.961"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ewx.0000480714.99599.84"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161162"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2018.1442159"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2018.1442160"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12715"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12503"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12781"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13393"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2525"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0980"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5237642"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/nu8120789"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/238\/3\/404\/3979851\/000517514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/238\/3\/404\/3979851\/000517514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:06:02Z","timestamp":1745420762000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,2]]},"published-print":{"date-parts":[[2022,5,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000517514","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.15105102","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]}}}