{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:30:49Z","timestamp":1762918249185,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Current guidelines for the treatment of noncystic fibrosis bronchiectasis (NCFB) recommend pulmonary rehabilitation (PR), but to date, there are few studies that have proven its effectiveness. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The main objective of this study was to examine the effect of PR on pulmonary function tests and exercise capacity. &lt;b&gt;&lt;i&gt;Method:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to systematically review the effects of PR in NCFB on (1) forced expiratory volume in the first second (FEV&lt;sub&gt;1&lt;\/sub&gt;) and (2) exercise capacity evaluated by the 6-min walk test (6MWT) and the incremental shuttle walk test (ISWT). This meta-analysis was undertaken according to PRISMA recommendations. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This pair-wise meta-analysis included data obtained from studies that enrolled 529 NCFB patients. The FEV&lt;sub&gt;1&lt;\/sub&gt; assessment after PR between the active and control group did not show any significant increase (FEV&lt;sub&gt;1&lt;\/sub&gt; difference 0.084 mL; CI: \u22120.064, +0.233; &lt;i&gt;p&lt;\/i&gt; = 0.264), and there was an increasing trend (188 mL; CI: \u22120 to 0.009, +0.384) at the limits of statistical significance (&lt;i&gt;p&lt;\/i&gt; = 0.061). Walked distance showed a significant increase in the PR group compared to the control group (ISWT distance difference 070.0 m; CI: 55.2, 84.8; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), and this finding was confirmed before and after PR both by the ISWT (68.85 m greater than baseline; CI: 40.52, 97.18; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) and by the 6MWT (37.7 m greater than baseline; CI: 20.22, 55.25; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; PR improves exercise tolerance in NCFB patients, but it has a modest impact on respiratory function. <\/jats:p>","DOI":"10.1159\/000517527","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T21:00:50Z","timestamp":1628197250000},"page":"97-105","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary Rehabilitation in Noncystic Fibrosis 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Ludovica","family":"Ritondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xhesika","family":"Pata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Spada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Rogliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012519"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005613"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1479972310391282"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e3182631314"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0490"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.739"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-44"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.06.028"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.11.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00055509"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.05.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0368-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.646"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.08.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.028928"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13397"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5152\/TurkThoracJ.2018.18093"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000380771"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150414"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.07.006"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)60490-0"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9703055"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-115"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0804632"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-018-0094-x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2019.1606189"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002166"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4315"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:06:14Z","timestamp":1745420774000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,6]]},"published-print":{"date-parts":[[2022,1,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000517527","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2021,8,5]]}}}