{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:18Z","timestamp":1787017938881,"version":"build-2736575974"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> This study aimed to determine the preoperative clinicophysiological and postoperative clinicopathological predictors of malignancy in patients with intraductal papillary mucinous neoplasm (IPMN). <b><i>Methods:<\/i><\/b> This was a retrospective observational study. We included 121 patients (73 men and 48 women; mean age: 68.7 years) who had undergone pancreatic resection for IPMN between 2007 and 2018. These patients were grouped into invasive carcinoma (IPMN-INV, <i>N<\/i> = 21) and low\/high-grade IPMN (IPMN-LG\/HG, <i>N<\/i> = 100) groups. Univariate and multivariate analyses of clinicophysiological parameters were carried out. These parameters were also compared between the IPMN-INV\/HG (<i>N<\/i> = 53) and IPMN-LG (<i>N<\/i> = 68) groups. Survival analyses according to macroscopic type and IPMN subtypes were performed. <b><i>Results:<\/i><\/b> On univariate analysis, age (<i>p<\/i> = 0.038), carbohydrate antigen (CA) 19-9 (<i>p<\/i> &#x3c; 0.001), IPMN macroscopic type (<i>p<\/i> = 0.001), IPMN subtype (<i>p<\/i> &#x3c; 0.001), pancreatic duct diameter (<i>p<\/i> &#x3c; 0.001), and mural nodule (<i>p<\/i> = 0.042), between IPMN-INV and IPMN-LG\/HG were found to be significant prognostic factors of malignancy. CA 19-9 was found to be an independent prognostic factor of IPMN malignancy on multivariate analysis (<i>p<\/i> = 0.035). The 1-, 3-, and 5-year overall survival (OS) rates of the IPMN-INV and IPMN-LG\/HG groups were 94.4\/100%, 94.4\/100%, and 67.2\/100%, respectively. The OS rate in the IPMN-LG\/HG group was significantly higher than that in the IPMN-INV group (<i>p<\/i> &#x3c; 0.001). On univariate analysis, platelet (<i>p<\/i> = 0.043), CA 19-9 (<i>p<\/i> = 0.039), prognostic nutritional index (<i>p<\/i> = 0.034), platelet\/lymphocyte ratio (<i>p<\/i> = 0.01), IPMN macroscopic type (<i>p<\/i> &#x3c; 0.001), IPMN subtype (<i>p<\/i> &#x3c; 0.001), pancreatic duct diameter (<i>p<\/i> = 0.036), and mural nodule (<i>p<\/i> = 0.032) between IPMN-INV\/HG and IPMN-LG were found to be significant prognostic factors of malignancy. On multivariate analysis, CA 19-9 was found to be an independent prognostic factor (<i>p<\/i> = 0.042) between IPMN-INV\/HG and IPMN-LG of malignancy. The 1-, 3-, and 5-year OS rates of the IPMN-INV\/HG and IPMN-LG groups were 97.9\/100%, 97.9\/100%, and 82.6\/100%, respectively. The OS rate was significantly higher in the IPMN-LG group than in the IPMN-INV\/HG group (<i>p<\/i> = 0.03). No significant differences in survival were observed in patients with macroscopic tumors (<i>p<\/i>= 0.544). <b><i>Conclusion:<\/i><\/b> CA 19-9 is an independent invasive malignancy predictor of IPMN.<\/jats:p>","DOI":"10.1159\/000517558","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T17:01:15Z","timestamp":1628010075000},"page":"262-270","source":"Crossref","is-referenced-by-count":7,"title":["Carbohydrate Antigen 19-9 Is an Invasive Malignancy Preoperative Prognostic Factor for Intraductal Papillary Mucinous Neoplasms"],"prefix":"10.1159","volume":"62","author":[{"given":"Shuji","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsugi","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Nishda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Orimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Nagakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-019-01931-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61024-0_1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000533"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36552"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.210567"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318258055c"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602305"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001988"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003108"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006599"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2887-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001985"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.04.007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.376"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.02.010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-2982-z"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:06:36Z","timestamp":1745406396000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,11,23]]},"published-print":{"date-parts":[[2021,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000517558","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}