{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:19:34Z","timestamp":1773505174673,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to understand physical characteristics of Embosphere microspheres for the clinical use of microsphere chemotherapy embolization of liver cancer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The morphology of Embosphere microspheres in different states, including static, oscillating, and in a magnetic field was observed with the naked eye. Ninety-five patients diagnosed with primary hepatocellular carcinoma (HCC) were separated into 3 groups based on the types of embolic material as follows: 32 cases of sole microspheres, 34 cases of iodinated oil (17 cases with additional application of gelatin sponge particle), and 29 cases of iodinated oil + Embosphere microspheres. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The diameter of the microspheres ranged from 100 to 300 \u03bcm, with a sedimentation rate \u03c5 = 0.0375 cm\/s in physiological saline. The diameter of microspheres ranged from 300 to 500 \u03bcm, with a sedimentation rate \u03c5 = 0.1875 cm\/s. The swelling rate of microspheres was 90%. Microspheres showed nondirectional movement in a 1.5- or 3.0-T magnetic field during magnetic resonance imaging. A volumetric ratio of 1:1.4\u20131:1.5 between microspheres and contrast agent resulted in optimal suspension properties. Microspheres appeared circular with a smooth surface upon water adsorption. Microsphere embolism was observable in blood vessels of pathological sections. The surface of microspheres can adsorb 5-fluorouracil and arsenic trioxide. There are statistically significant differences in local-regional tumor control conditions among patients treated with sole microspheres, iodinated oil, and iodinated oil + microspheres during transarterial chemoembolization. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Embosphere microspheres can be used to embolize patients with rupture and hemorrhage of HCC. Embosphere microsphere embolization is superior to iodinated oil and iodinated oil + microsphere for HCC. <\/jats:p>","DOI":"10.1159\/000517680","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T21:01:15Z","timestamp":1628024475000},"page":"139-155","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the Physical Properties and Clinical Application of Embosphere Microspheres"],"prefix":"10.1159","volume":"66","author":[{"given":"Yinbao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9191"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110315"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v9.i18.808"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0847"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12435"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5081-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5754\/hge12030"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003503"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50047"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08649-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.2.3031724"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2380"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2020.102169"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1368-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/0284185116648501"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34778"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1344336"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:07:31Z","timestamp":1745420851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,10,11]]},"published-print":{"date-parts":[[2021,10,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000517680","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}