{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:00:46Z","timestamp":1762981246010,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to prospectively gather data on pregnancy outcomes of prenatally diagnosed trisomy 21 (T21) in a large tertiary referral centre. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data were gathered prospectively in a large tertiary referral centre over 5 years from 2013 to 2017 inclusively. Baseline demographic and pregnancy outcome data were recorded on an anonymized computerized database. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There were 1,836 congenital anomalies diagnosed in the study period including 8.9% (&lt;i&gt;n&lt;\/i&gt; = 165) cases of T21. 79% (&lt;i&gt;n&lt;\/i&gt; = 131) were age 35 or older at diagnosis. 79\/113 (69.9%) women chose a termination of pregnancy (TOP) following a diagnosis of T21. Amongst pregnancies that continued, there were 4 second-trimester miscarriages (4\/34, 11.7%), 9 stillbirths (9\/34, 26.4%), and 1 neonatal death, giving an overall pregnancy and neonatal loss rate of 14\/34 (41.1%). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The risk of foetal loss in prenatally diagnosed T21 is high at 38% with an overall pregnancy loss rate of 41.1%. This information may be of benefit when counselling couples who are faced with a diagnosis of T21 particularly in the context of limited access to TOP. <\/jats:p>","DOI":"10.1159\/000517729","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:01:39Z","timestamp":1632862899000},"page":"575-581","source":"Crossref","is-referenced-by-count":5,"title":["The Natural History of Trisomy 21: Outcome Data from a Large Tertiary Referral Centre"],"prefix":"10.1159","volume":"48","author":[{"given":"Clare","family":"O\u2019Connor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"McParland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cathcart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhona","family":"Mahony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionnuala","family":"McAuliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0696-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0223(199909)19:9%3c808::aid-pd637%3e3.0.co;2-b"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.6.482"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1253-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1053"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.11.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2012.04.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6831.867"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)11280-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3426"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-2011.2011.00109.x"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:07:37Z","timestamp":1745420857000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,10,22]]},"published-print":{"date-parts":[[2021,10,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000517729","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2021]]}}}