{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:31:42Z","timestamp":1787160702300,"version":"build-2736575974"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Objectives:<\/i><\/b> The optimal excision margin of primary cutaneous melanoma greater than 2 mm in thickness is still a controversial topic. The aim of the present study was to compare the long-term survival between narrow and wide excision margins in the surgical excision of patients with high-risk primary melanoma. <b><i>Methods:<\/i><\/b> We chose the patients with primary melanoma of the skin thicker than 2 mm in The Surveillance, Epidemiology, and End Results database. Patients were divided into a narrow margin group (1\u20132 cm) and a wide margin group (&#x3e;2 cm) according to the resection margin information. The primary outcome was overall survival and disease-specific survival. <b><i>Results:<\/i><\/b> From 2004 to 2015, a total of 2,772 patients diagnosed as having melanoma of the skin were recruited into this study and were assigned to the narrow margin group (<i>n<\/i> = 1996) and the wide margin group (<i>n<\/i> = 776). A total of 1,098 patients died during the follow-up, and 681 of these were due to melanoma. There were 779 deaths in the narrow margin group and 319 deaths in the wide margin group (HR: 0.96, 95% CI: 0.84\u20131.10, <i>p<\/i> = 0.26). A total of 490 melanoma-specific deaths were reported in the narrow margin group and 191 were reported in the wide margin group (HR: 1.01, 95% CI: 0.85\u20131.19, <i>p<\/i> = 0.91). <b><i>Conclusions:<\/i><\/b> Wider excision margin greater than 2 cm did not provide any additional therapeutic benefits compared to narrow excision margin between 1 and 2 cm. A 2-cm margin is adequate and safe for high-risk primary melanoma of the skin thicker than 2 mm.<\/jats:p>","DOI":"10.1159\/000517828","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T17:00:57Z","timestamp":1637773257000},"page":"534-541","source":"Crossref","is-referenced-by-count":2,"title":["Excision Margin and Survival in Patients with High-Risk, Primary Cutaneous Melanoma: A Retrospective Study Based on Surveillance Epidemiology and End Result (SEER) Database"],"prefix":"10.1159","volume":"238","author":[{"given":"Meng-Nan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205417"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.09.038"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2019.09.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02115.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.5812"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.09.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmir.2019.05.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0021-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3402"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31132-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-1-20"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000394"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00278"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030681"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00482-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61546-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07866-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1071\/HC17055"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:08:07Z","timestamp":1745406487000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,2]]},"published-print":{"date-parts":[[2022,5,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000517828","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]}}}