{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:40:28Z","timestamp":1789094428244,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Endoscopy remains the exam of choice in the evaluation of activity in Crohn\u2019s disease (CD) after surgery (ACD-AS). However, intestinal ultrasound (IUS) may represent a noninvasive alternative. The objective of this study is to determine the diagnostic accuracy of this modality compared to endoscopy. <b><i>Material and Methods:<\/i><\/b> This is a cross-sectional study, comprising a period of 14 months, carried out in patients with established CD and ileocecal resection due to the disease. IUS (HI-VISION Avius\u00ae, Tokyo, Japan) was performed with linear probe B-mode\/Doppler prior to ileocolonoscopy. IUS and ileocolonoscopy were performed on the same day by 2 specialists in Gastroenterology dedicated to ultrasound and inflammatory bowel disease, in a double-blind mode. Collected demographic and clinical data (Harvey-Bradshaw Index [HBI]; remission \u22644), serological\/fecal inflammatory parameters (leukocytes [4\u201310 \u00d7 10<sup>9<\/sup> cells\/L], C-reactive protein [\u22640.5 mg\/dL], and fecal calprotectin [&#x3c;50 mg\/kg]), endoscopy (Rutgeerts score: remission &#x3c;i2), and ultrasound (intestinal wall thickening [\u22643 mm] and digestive wall vascularization using the semiquantitative score of Limberg [absent = 0, sparse = 1, moderate = 2, and marked = 3]). <b><i>Results:<\/i><\/b> Thirty-nine patients (female: 64.1%, mean age: 43.5 \u00b1 15.3 years) were included. The median post-surgery follow-up was 9 years (IQR 3\u201312). The Montreal classification was as follows: L1, 61.5% (<i>n<\/i> = 24); L3, 38.5% (<i>n<\/i> = 15); B1 and B2, 28.2% (<i>n<\/i> = 11); and B3, 43.6% (<i>n<\/i> = 17). Most patients were in clinical remission (87.2%; <i>n<\/i> = 34), with a mean HBI of 2.1 \u00b1 2.2. Twenty-two patients (56.4%) had normal inflammatory markers. IUS (intestinal wall thickening &#x3e;3 mm and\/or Limberg score &#x3e;1) was abnormal in 61.5% (<i>n<\/i> = 24) of the cases. Endoscopic remission (Rutgeerts score &#x3c;i2) in 53.8% (<i>n<\/i> = 21) of the cases. Compared to endoscopy, IUS (area under the receiver operating characteristic curve [AUROC] = 0.75, <i>p<\/i> = 0.007) showed a diagnostic accuracy superior to that of inflammatory parameters (AUROC = 0.66, <i>p<\/i> = 0.083) and clinical parameters (AUROC = 0.64, <i>p<\/i> = 0.139). IUS showed a moderate concordance with endoscopy (\u03ba = 0.5, <i>p<\/i> = 0.001), which was higher than that with inflammatory parameters (\u0138 = 0.33, <i>p<\/i> = 0.041) or clinical parameters (\u0138 = 0.29, <i>p<\/i> = 0.01). <b><i>Conclusions:<\/i><\/b> Ultrasound evaluation of the digestive wall is a noninvasive technique that shows a good diagnostic accuracy and a moderate concordance with endoscopy, being superior to clinical and serological\/fecal inflammatory parameters. <\/jats:p>","DOI":"10.1159\/000517999","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T21:00:35Z","timestamp":1628802035000},"page":"178-186","source":"Crossref","is-referenced-by-count":12,"title":["Role of Intestinal Ultrasound in the Evaluation of Postsurgical Recurrence in Crohn\u2019s Disease: Correlation with Endoscopic Findings"],"prefix":"10.1159","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-3074","authenticated-orcid":false,"given":"Cl\u00e1udia\u00a0Patricia","family":"Macedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-8618","authenticated-orcid":false,"given":"Mara","family":"Sarmento\u00a0Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-8757","authenticated-orcid":false,"given":"Elisa","family":"Gravito-Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-2475","authenticated-orcid":false,"given":"Marta","family":"Gravito-Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Margarida","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6124","authenticated-orcid":false,"given":"Francisco","family":"Portela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-6341","authenticated-orcid":false,"given":"Pedro","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200001000-00006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90613-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.03.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20909"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-0225-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.01.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6593"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.05.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.034"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22861"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.02.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14393"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20275"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.02.020"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818771367"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200606000-00007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00340.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy113"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.777774"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(08)60536-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000727"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.12.014"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40267.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.457"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/517999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:10:12Z","timestamp":1745421012000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000517999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,5]]},"published-print":{"date-parts":[[2022,5,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000517999","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}