{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:50:25Z","timestamp":1751421025133,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> The usefulness of adjuvant chemotherapy in biliary tract cancer (BTC) is poorly reported. This study aimed to evaluate the effectiveness and safety of adjuvant gemcitabine plus S-1 (GS) chemotherapy after curative surgical resection for BTC. <b><i>Methods:<\/i><\/b> 225 BTC patients who underwent surgical resection between January 2006 and May 2019 were enrolled in this study. Twenty-seven patients received adjuvant chemotherapy with GS (GS group), whereas 67 patients underwent surgery alone (S group). Twenty-three matching pairs were derived through propensity score (PS) matching analysis. Patients received 12 cycles of adjuvant chemotherapy (70 mg\/m<sup>2<\/sup> oral S-1 for 7 consecutive days plus intravenous gemcitabine 1,000 mg\/m<sup>2<\/sup> on day 7). The primary end point was recurrence-free survival (RFS). The secondary end points were the 1-, 2-, and 3-year RFS and overall survival (OS) rates, tolerability, and frequency of grade 3\/4 toxicity. <b><i>Results:<\/i><\/b> The completion rate was 81.5%; no treatment-related deaths were observed. Grade 3\/4 adverse events were seen in 40.7% of the patients. RFS (3-year RFS rate: 59.3% vs. 39.1%, <i>p<\/i> = 0.049) and OS (3-year OS rate: 71.7% vs. 53.4%, <i>p<\/i> = 0.008) were significantly better in the GS group than in the S group among PS-matched pairs. <b><i>Discussion\/Conclusion:<\/i><\/b> GS chemotherapy after curative surgery was well tolerated, showed better clinical benefit in the adjuvant setting, and can effectively reduce BTC recurrence. <\/jats:p>","DOI":"10.1159\/000518094","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T21:00:43Z","timestamp":1629925243000},"page":"703-712","source":"Crossref","is-referenced-by-count":1,"title":["Survival Outcomes of Gemcitabine Plus S-1 Adjuvant Chemotherapy after Surgical Resection for Advanced Biliary Tract Cancer"],"prefix":"10.1159","volume":"99","author":[{"given":"Kiyotaka","family":"Hosoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-1697","authenticated-orcid":false,"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Notake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Sugenoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koya","family":"Yasukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-008-0015-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008352123009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602208"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0095-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0673-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000195538"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011746.pub2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1115-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-017-0430-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0b013e3181b0fc8b"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-011-0498-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.05.010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10831"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.7352"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10776"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00050"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002865"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30915-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1498-0"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:11:16Z","timestamp":1745421076000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,11,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000518094","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2021]]}}}