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Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate the expression patterns of glucose metabolism-related proteins and their clinicopathologic implications in adrenal cortical neoplasms (ACN) and pheochromocytoma (PCC). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Immunohistochemical staining was performed to evaluate glucose metabolism-related proteins (GLUT1, CAIX, hexokinase II, G6PDH, PHGDH, and SHMT1) in 132 ACN cases (115 adrenal cortical adenoma [ACA] and 17 adrenal cortical carcinoma [ACC]) and 189 PCC cases. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Expression levels of GLUT1 in tumor cells ([T]; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), GLUT1 in stromal cells ([S]; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), G6PDH (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), and SHMT1 (&lt;i&gt;p&lt;\/i&gt; = 0.002) were higher in ACN than in PCC. GLUT1 (T; &lt;i&gt;p&lt;\/i&gt; = 0.045) and PHGDH (&lt;i&gt;p&lt;\/i&gt; = 0.043) levels were higher in ACC than in ACA. In a univariate analysis of ACN, GLUT1 (T; &lt;i&gt;p&lt;\/i&gt; = 0.017), CAIX (S; &lt;i&gt;p&lt;\/i&gt; = 0.003), and PHGDH (&lt;i&gt;p&lt;\/i&gt; = 0.009) levels were correlated with a shorter overall survival (OS). GLUT1 (T; &lt;i&gt;p&lt;\/i&gt; = 0.001) and PHGDH (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) were related to a shorter OS in PCC. GLUT1 (T) positivity (&lt;i&gt;p&lt;\/i&gt; = 0.043) in ACN predicted a poor OS in a multivariate Cox analysis. In PCC, high GAPP score (&lt;i&gt;p&lt;\/i&gt; = 0.026), GLUT1 (T; &lt;i&gt;p&lt;\/i&gt; = 0.002), and PHGDH (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) were independent prognostic factors for poor OS. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The adrenal gland tumors ACN and PCC had different expression patterns of glucose metabolism-related proteins (GLUT1, G6PDH, and SHMT1), with higher expression levels in ACN than in PCC. GLUT1 and PHGDH were significant prognostic factors in these adrenal neoplasms. <\/jats:p>","DOI":"10.1159\/000518208","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T21:03:57Z","timestamp":1631221437000},"page":"424-433","source":"Crossref","is-referenced-by-count":2,"title":["Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms"],"prefix":"10.1159","volume":"88","author":[{"given":"Eun Kyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja 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