{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:07:30Z","timestamp":1790701650214,"version":"4.1.0"},"reference-count":86,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>While the Hedgehog signalling pathway is implicated in numerous developmental processes and maladies, variants in the &lt;i&gt;Desert Hedgehog&lt;\/i&gt; (&lt;i&gt;DHH&lt;\/i&gt;) ligand underlie a condition characterised by 46,XY gonadal dysgenesis with or without peripheral neuropathy. We discuss here the role and regulation of &lt;i&gt;DHH&lt;\/i&gt; and its signalling pathway in the developing gonads and examine the current understanding of how disruption to this pathway causes this difference of sex development (DSD) in humans. <\/jats:p>","DOI":"10.1159\/000518308","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T21:00:34Z","timestamp":1631134834000},"page":"98-111","source":"Crossref","is-referenced-by-count":17,"title":["The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex 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