{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:27:35Z","timestamp":1771057655569,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Transient neonatal diabetes mellitus (TNDM) is a rare condition that is characterized by the presence of diabetes mellitus during the first 6 months of life and remission by 18 months of age. It usually relapses at a median age of 14 years. Hyperinsulinaemic hypoglycaemia is a relatively common complication during remission. Although \u03b2-cell function is reported to be impaired at relapse, the clinical course of glycaemic profiles during remission in patients with TNDM remains largely unknown. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; Longitudinal glycaemic profiles were investigated annually from remission (185 days) to relapse (14.5 years) in a patient with TNDM due to paternal 6q24 duplication using the oral glucose tolerance test (glucose intake: 1.75 g\/kg to a maximum of 75 g). The patient\u2019s \u03b2-cell function and insulin sensitivity were assessed by calculating the insulinogenic index, homeostasis model assessment of \u03b2-cell function (HOMA-\u03b2), homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index, and Matsuda index. Early insulin response to glucose intake was impaired throughout remission, whereas fasting insulin and \u03b2-cell function by HOMA-\u03b2 gradually increased in the first few years since remission, followed by a gradual decline in function. In contrast, HOMA-IR fluctuated and peaked at 6.5 years of age. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This is the first report of annual longitudinal glycaemic profiles in a patient with 6q24-related TNDM during remission. We identified fluctuations in \u03b2-cell function and insulin resistance during remission. <\/jats:p>","DOI":"10.1159\/000518617","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T22:15:48Z","timestamp":1634595348000},"page":"229-234","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal Glycaemic Profiles during Remission in 6q24-Related Transient Neonatal Diabetes Mellitus"],"prefix":"10.1159","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-096X","authenticated-orcid":false,"given":"Yasuhiro","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-0325","authenticated-orcid":false,"given":"Tsuyoshi","family":"Isojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Takamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahoko","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Enkai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishin","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-4775","authenticated-orcid":false,"given":"Tohru","family":"Yorifuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Mimaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0029"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13199"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.8.1359"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0324"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60098-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2017.10.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70059-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127089"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2494"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.030502"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30272"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2766-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1236-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.20.47"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.25.71"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2170"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.7.6661"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19876"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.10.2405"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.29.179"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.1.56"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:17:29Z","timestamp":1745421449000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":23,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2021,10,18]]},"published-print":{"date-parts":[[2021,11,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000518617","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}