{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:43:13Z","timestamp":1790962993113,"version":"4.1.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Respiratory failure from acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is associated with high mortality. Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) has been reported to have beneficial effects on patients with AE-IPF. Whether patient characteristics influence the extent of this benefit remains unclear. <b><i>Methods:<\/i><\/b> We retrospectively examined the records of 30 patients with AE-IPF who underwent PMX-DHP. The favorable factors of survival were determined using Cox proportional hazards analyses. <b><i>Results:<\/i><\/b> The 1- and 12-month survival rates after PMX-DHP were 70.0% and 50.0%, respectively. The multivariate analysis revealed that low modified Gender-Age-Physiology (GAP) index (\u22648 points) (hazard ratio [HR] 0.317, <i>p<\/i> = 0.015) and PMX-DHP received within 48 h of steroid pulse (HR 0.289, <i>p<\/i> = 0.012) were favorable factors. Notably, even in the patients with high modified GAP index (&#x3e;8 points), that is, more advanced IPF, those who received PMX-DHP within 48 h of steroid pulse had a better prognosis than those who did after 48 h of the steroid pulse (<i>p<\/i> = 0.032). <b><i>Conclusions:<\/i><\/b> Early PMX-DHP initiation in patients with AE-IPF, specifically within 48 h after the steroid pulse therapy, may improve prognosis regardless of the severity of chronic phase of IPF before AE-IPF. <\/jats:p>","DOI":"10.1159\/000518705","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T21:03:57Z","timestamp":1631221437000},"page":"485-491","source":"Crossref","is-referenced-by-count":5,"title":["Improved Prognostic Prediction by Combination of Early Initiation of Polymyxin B Hemoperfusion with Modified Gender-Age-Physiology Index in Acute Exacerbation of Idiopathic Pulmonary Fibrosis"],"prefix":"10.1159","volume":"51","author":[{"given":"Keiji","family":"Oishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arata","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriyuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-7311","authenticated-orcid":false,"given":"Yusuke","family":"Mimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Asami-Noyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kakugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunahiko","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000287232"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000330325"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000320128"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6965"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.032"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2687"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0004-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6056"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2017.05.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2020.04.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5160694"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000510290"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:18:37Z","timestamp":1745421517000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,1]]},"published-print":{"date-parts":[[2022,6,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000518705","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]}}}