{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:18Z","timestamp":1791380598391,"version":"4.3.3"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Portal hypertension leads to pronounced venous collateralization and development of varices. Besides manifest liver cirrhosis, primarily left-sided portal hypertension is causal for the development of gastric varices. We present a case of a 36-year-old female patient with splenomegaly, underlying primary myelofibrosis, and detection of somatic Janus-kinase-2 driver-mutation JAK2V617F. Following first upper gastrointestinal bleeding, isolated gastric varices could be detected as a result of underlying left-sided portal hypertension. Within a few months, repeated life-threatening bleedings with transfusion requirements and frequent hospitalizations occurred. Despite multiple injections of cyanoacrylates, the proven therapy of choice, varices could not be stabilized. Combination of targeted JAK-inhibitor therapy in conjunction with the use of EUS-guided application of coils with subsequent cyanoacrylate injection resulted in acute and long-term bleeding control. <\/jats:p>","DOI":"10.1159\/000518766","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T06:33:43Z","timestamp":1631169223000},"page":"530-534","source":"Crossref","is-referenced-by-count":3,"title":["Recurrent Upper Gastrointestinal Bleeding from Isolated Gastric Varices as Primary Symptom of Myelofibrosis: A Case Report on Combining Interventional and Pharmacologic Treatment Options"],"prefix":"10.1159","volume":"40","author":[{"given":"Benjamin","family":"Giszas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian H.","family":"Heidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-475X","authenticated-orcid":false,"given":"Philipp A.","family":"Reuken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3941\/jrcr.v4i10.512"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000329888"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/673781"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.4886"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-116856"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.08.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03625-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-019-0117-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/a-0902-4384"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21145"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.08.013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.794269"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110557"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:11Z","timestamp":1745421551000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000518766","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]}}}