{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:57Z","timestamp":1745468637619,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objectives:<\/i><\/b> The aim of this study was to investigate a possible association between changes in low parathyroid hormone (PTH) levels and cardiac function decline in maintenance hemodialysis (MHD) patients. <b><i>Methods:<\/i><\/b> A total of 150 MHD patients were included and followed for 24 months. The enrolled patients were divided into 3 groups based on their PTH status at baseline and 24 months. Factors potentially involved in changes in the PTH level and cardiac function were compared using multivariate logistic regression analysis. <b><i>Results:<\/i><\/b> At 24 months, the presence of low PTH levels increased by 26.7%. The main independent factors for low PTH levels were a low BMI, hemoglobin, and serum albumin and high serum calcium (<i>p<\/i> &#x3c; 0.05). A persistently low PTH level at 24 months was associated with a decrease in the left ventricular ejection fraction (LVEF) and increase in valvular calcification (<i>p<\/i> &#x3c; 0.05). Additionally, a decrease in PTH levels from normal or high to low values was associated with a decrease in LVEF and cardiac output (CO) and an increase in valvular calcification (<i>p<\/i> &#x3c; 0.05). Furthermore, compared with those of the persistently low PTH level group, LVEF values were lower at 24 months in the group with a decrease from high\/normal to low PTH level (<i>p<\/i> &#x3c; 0.05). <b><i>Conclusion:<\/i><\/b> Persistently low PTH levels and changes in the PTH level from high\/normal to low were associated with cardiac function decline in MHD patients. Moreover, a PTH level change from high\/normal to low showed a stronger correlation with cardiac function decline. <\/jats:p>","DOI":"10.1159\/000518791","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T21:00:48Z","timestamp":1627678848000},"page":"550-556","source":"Crossref","is-referenced-by-count":0,"title":["The Association between Changes in Low Parathyroid Hormone Levels and Cardiac Function Decline in Maintenance Hemodialysis Patients: A Prospective Observational Study"],"prefix":"10.1159","volume":"30","author":[{"given":"Xiao-han","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-si","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-dan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60384-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.07.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.12.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000903"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs404"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02448-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001278"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2009.10.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6410"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq541"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030208"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.892577"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.414"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31827981be"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174811"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:19:22Z","timestamp":1745421562000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,12,16]]},"published-print":{"date-parts":[[2022,1,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000518791","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2021]]}}}