{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:43:31Z","timestamp":1789872211549,"version":"4.0.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"11-12","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Anisakiasis is a common disease in countries such as Japan, where raw or undercooked marine fish are frequently consumed. The disease is caused by accidental ingestion of a live larva of <i>Anisakis<\/i> in raw or undercooked marine fish. In typical cases, it causes abrupt gastrointestinal symptoms, such as epigastric pain, nausea, and vomiting. According to a published report, the disease was alleviated by oral ingestion of an over-the-counter drug containing wood creosote. <b><i>Methods:<\/i><\/b> We performed an in vitro experiment to elucidate whether wood creosote can inhibit the motor activity of <i>Anisakis<\/i> larvae, using infrared locomotion tracking and agarose gel penetration techniques. <b><i>Results:<\/i><\/b> Our results clearly demonstrate that wood creosote inhibits the motor activity of <i>Anisakis<\/i> larvae. The concentration of wood creosote used in our experiment is similar to that found in stomach juice when a usual oral dose is taken of the medicine containing wood creosote. <b><i>Discussion\/Conclusion:<\/i><\/b> Our results suggest the potential usefulness of the medicine containing wood creosote in the treatment of acute <i>Anisakis<\/i> infection of the gastrointestinal tract. <\/jats:p>","DOI":"10.1159\/000518961","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T21:00:33Z","timestamp":1631912433000},"page":"637-643","source":"Crossref","is-referenced-by-count":6,"title":["The Inhibitory Effect of Wood Creosote on the Movement of <b><i>Anisakis<\/i><\/b> Larvae: An Implication for the Treatment of Acute Anisakiasis"],"prefix":"10.1159","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-730X","authenticated-orcid":false,"given":"Norio","family":"Ogata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Tagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2011.1076"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(91)90010-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350310106036"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijppaw.2019.04.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12349"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00916-18"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2020.08.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2017.12.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203671"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00012-07"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12399"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.157.2.4048435"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2006132099"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5754\/hge11052"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06144-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(86)90032-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0395:EOIAAA]2.0.CO;2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(99)00178-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.03.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X17001158"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.11.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2004.10.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000028322"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000139043"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000139111"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000056092"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-5764-3"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091499"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13982"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.035"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c20-00583"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:20:57Z","timestamp":1745421657000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":31,"journal-issue":{"issue":"11-12","published-online":{"date-parts":[[2021,11,9]]},"published-print":{"date-parts":[[2021,11,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000518961","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}