{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:29:01Z","timestamp":1791725341257,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; This study aimed to evaluate the outcomes of juxtapapillary choroidal melanomas treated with notched ruthenium-106 plaques. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Juxtapapillary choroidal melanomas (tumours within 2 disc diameters from the optic disc) treated with notched ruthenium-106 plaques (Eckert &amp;amp; Ziegler, BEBIG, Berlin, Germany) at the Scottish Ocular Oncology Service between 2009 and 2015 were retrospectively reviewed. The data were analysed with respect to various outcome measures including recurrence, complications, vision, and eye preservation. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We reviewed 40 patients with a median tumour diameter of 8.4 mm (range 5\u201317 mm) and a median thickness of 2.5 mm (range 1.1\u20136 mm). AJCC tumour category distribution was 62.5% T1, 32.5% T2, and 5% T3 tumours. The mean presenting vision was 0.3 logMAR, and the mean final vision was 0.7 logMAR, with 62.5% retaining &amp;#x3e;1.0 logMAR and 50% retaining &amp;#x3e;0.3 logMAR at the final follow-up. The median follow-up was 51 months (14\u2013100 months). Over the maximum follow-up time, 13 tumours (32.5%) recurred. Six of these were treated with salvage proton beam therapy (PBT), 2 with transpupillary thermotherapy followed by PBT, and 5 with enucleation. The final eye retention rate was 87.5%. Complications included maculopathy (10%), retinal detachment (5%), neovascular glaucoma (2.5%), and diplopia (2.5%). The observed risk of recurrence over 5 years was 31% (95% CI: 14.1%, 47.8%), and the risk of enucleation over 5 years was 11.5% (95% CI: 0.9%, 21.8%). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Juxtapapillary choroidal melanomas treated with notched ruthenium plaques have a high recurrence rate and frequently need salvage treatment with PBT for tumour control. This has led to a change in our practice toward offering PBT as the first-line treatment for these patients. <\/jats:p>","DOI":"10.1159\/000518975","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T21:01:16Z","timestamp":1629752476000},"page":"411-417","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes following Notched Ruthenium-106 Plaque Brachytherapy for Juxtapapillary Choroidal Melanomas"],"prefix":"10.1159","volume":"7","author":[{"given":"Manvi Manu","family":"Sobti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Edington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"McLernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Schipani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Chadha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.12.715"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.8.732"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.11.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(97)00088-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.11.008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.111"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90456-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.2.109"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.01.025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.11.844"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2016.17.12.5281"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.7.933"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90487-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.022"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.11.1515"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/107327480401100504"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302490"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.195594"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.109"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/518975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:21:06Z","timestamp":1745421666000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000518975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,12,17]]},"published-print":{"date-parts":[[2022,1,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000518975","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}