{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:55:13Z","timestamp":1778500513139,"version":"3.51.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Cerebral ischemia and reperfusion (CI\/R) injury is a devasting cerebrovascular disease, accompanied with ischemia stroke, cerebral infarction. Zuogui Pill (ZGP), as a Chinese traditional medicine, is proved to be effective in many diseases and cancers. Our study aimed to detect the roles of ZGP in CI\/R injury. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Neural stem cells were isolated from rats and induced by oxygen and glucose deprivation and recovery. CCK-8 and flow cytometry were applied to assess the function of ZGP on cell viability and apoptosis. Rat CI\/R injury models were established by the middle cerebral artery occlusion and reperfusion. The function of ZGP on CI\/R injury was identified via evaluating modified neurological severity score, infarct area, and cognitive impairment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Compared to the control, the cell viability was obviously decreased in the oxygen and glucose deprivation and recovery (OGD\/R) group, while the adverse influence on cells was reversed by cultured plus 10% ZGP serum. Consistently, ZGP attenuated the influence of OGD\/R on cell apoptosis. More importantly, ZGP could alleviate CI\/R injury of rats by reducing neurological damage and infarct area and promoting cognitive function. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This study provided protective roles of ZGP on cell viability and apoptosis induced by OGD\/R. In addition, ZGP played protective roles on neuroinflammation and cognitive function in rats. <\/jats:p>","DOI":"10.1159\/000519010","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T22:00:31Z","timestamp":1636063231000},"page":"143-150","source":"Crossref","is-referenced-by-count":12,"title":["Zuogui Pill Attenuates Neuroinflammation and Improves Cognitive Function in Cerebral Ischemia Reperfusion-Injured Rats"],"prefix":"10.1159","volume":"29","author":[{"given":"Hong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaomei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70089-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0118-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308427"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1667-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000489241"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1274596"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4268\/cjcmm20160601"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-019-0270-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104939"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419841482"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36138-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00371"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.029"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3717391"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.55"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008097"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100512"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50137"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11571017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-013-1536-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i19.2823"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2352-17.2018"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119851260"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-016-2095-4"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20110910"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308022"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201803_14595"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20161222.016"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.136"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:21:24Z","timestamp":1745421684000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,4]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,7]]},"published-print":{"date-parts":[[2022,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000519010","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,4]]}}}