{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:09:36Z","timestamp":1787407776480,"version":"build-2736575974"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>The co-occurrence of thymoma and T-lymphoblastic lymphoma\/leukemia is an extremely rare but previously reported association that poses a diagnostic and therapeutic challenge. We describe a 67-year-old patient with long-standing untreated B1 thymoma that presented with constitutional symptoms and a painless soft tissue mass on the right chest wall. Pathological analysis of the biopsy from the mass demonstrated T-lymphoblastic leukemia\/lymphoma. The patient went through a complicated course, was refractory to several lines of therapy, and eventually underwent allogeneic hematopoietic stem cell transplantation in complete remission from a matched related donor. The association between thymoma and malignant neoplasms has been described in the literature, most notably with colorectal adenocarcinoma and thyroid cancer. Thymoma-associated leukemia is, however, extremely unusual, with limited reports in the literature. Distinguishing between thymoma and leukemia can be challenging and often requires meticulous diagnostic efforts. For patients with a past history of thymoma, awareness of this particular association should be bared in mind to allow earlier diagnosis and therapy. <\/jats:p>","DOI":"10.1159\/000519033","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T21:00:33Z","timestamp":1631912433000},"page":"106-111","source":"Crossref","is-referenced-by-count":4,"title":["T-Lymphoblastic Leukemia\/Lymphoma and Thymoma: A Case Report and Review of the Literature of a Rare Association"],"prefix":"10.1159","volume":"145","author":[{"given":"Nadav","family":"Mizrahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Kugler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yeshurun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Wolach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-013-0214-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.9.1142"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.792927"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2015.06.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1520993"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.05192"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1043\/0003-9985(2003)127%3ce76:CTACLL%3e2.0.CO;2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/030089161109700123"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197609)38:3%3c1414::aid-cncr2820380348%3e3.0.co;2-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.573"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.184769"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-056754"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0145-2126(99)00078-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-4608(01)00500-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.127"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205399"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1309\/K2FY-1TED-8GEG-FLNG"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1606-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61269"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:21:41Z","timestamp":1745421701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,21]]},"published-print":{"date-parts":[[2022,2,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000519033","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,17]]}}}