{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:56:58Z","timestamp":1773471418097,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Two patients, with non-small cell lung carcinoma treated with pembrolizumab, developed bilateral diffuse uveal melanocytic proliferation (BDUMP) with interesting histopathological features. The first patient developed a right ciliary body mass concurrently with BDUMP. The globe was enucleated. The ciliary body mass was a mitotically active epithelioid uveal melanoma, invading the trabecular meshwork and peripheral corneal stroma, with over 90% of the cells expressing Cyclin D1 protein. The melanoma showed no chromosome 3 or 8 changes. The background uvea showed diffuse, bland spindle cell melanocytic proliferation with much lower Cyclin D1 expression (around 10%). In the choroid, this population was punctuated by islands of pigmented epithelioid cells, some of which were necrotic. All these islands expressed a high level of Cyclin D1, and some islands expressed nuclear preferentially expressed antigen in melanoma (PRAME). The ciliary body mass, epithelioid cell islands, and the BDUMP all expressed c-Met (the receptor for hepatocyte growth factor [HGF]). The features were those of ciliary body melanoma and choroidal melanoma \u201ctumorlets,\u201d developing on a background of BDUMP. The second patient developed bilateral periocular skin pigmentation following a diagnosis of BDUMP, which when biopsied, showed dermal islands of paraneoplastic perivascular melanocytic cell proliferation. These cells also expressed c-Met protein. These observations implicate the HGF\/c-Met axis in the pathogenesis of BDUMP, the uveal melanomas in the ciliary body and choroid in the first patient and the paraneoplastic dermal melanocytic proliferation in the second patient. <\/jats:p>","DOI":"10.1159\/000519177","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T21:00:54Z","timestamp":1630011654000},"page":"418-427","source":"Crossref","is-referenced-by-count":8,"title":["Uveal Melanoma and Paraneoplastic Perivascular Dermal Melanocytic Proliferation in the Setting of Bilateral Diffuse Uveal Melanocytic Proliferation: The Potential Role of the Hepatocyte Growth Factor\/c-Met Axis in Their Pathogenesis"],"prefix":"10.1159","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-2594","authenticated-orcid":false,"given":"Hardeep Singh","family":"Mudhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashar M.","family":"Bata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-3168","authenticated-orcid":false,"given":"Hibba","family":"Quhill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Milman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-4987","authenticated-orcid":false,"given":"Sachin M.","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182618bab"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305893"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.4.261"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198700730-00001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.75.11.693"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.131"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.147314"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2071"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10962"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001134"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9570.1000740"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513094200"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1999.tb00503.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9040035"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0604-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.09.01522"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010097"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:22:58Z","timestamp":1745421778000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,12,17]]},"published-print":{"date-parts":[[2022,1,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000519177","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}