{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:53:05Z","timestamp":1784145185670,"version":"3.55.0"},"reference-count":80,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Mammalian male sex differentiation is triggered during embryogenesis by the activation of the Y-linked testis-determining gene &lt;i&gt;SRY&lt;\/i&gt;. Since insufficient or delayed expression of &lt;i&gt;SRY&lt;\/i&gt; results in XY gonadal sex reversal, accurate regulation of &lt;i&gt;SRY&lt;\/i&gt; is critical for male development in XY animals. In humans, dysregulation of &lt;i&gt;SRY&lt;\/i&gt; may cause disorders of sex development. Mouse &lt;i&gt;Sry&lt;\/i&gt; is the most intensively studied mammalian model of sex determination. &lt;i&gt;Sry&lt;\/i&gt; expression is controlled in a spatially and temporally stringent manner. Several transcription factors play a key role in sex determination as trans-acting factors for &lt;i&gt;Sry&lt;\/i&gt; expression. In addition, recent studies have shown that several epigenetic modifications of &lt;i&gt;Sry&lt;\/i&gt; are involved in sex determination as cis-acting factors for &lt;i&gt;Sry&lt;\/i&gt; expression. Herein, we review the current understanding of transcription factor- and epigenetic modifier-mediated regulation of &lt;i&gt;SRY&lt;\/i&gt;\/&lt;i&gt;Sry&lt;\/i&gt; expression. <\/jats:p>","DOI":"10.1159\/000519217","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:01:39Z","timestamp":1632862899000},"page":"351-359","source":"Crossref","is-referenced-by-count":23,"title":["Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene 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