{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:31:08Z","timestamp":1773441068824,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Guillain-Barr\u00e9 syndrome (GBS) is a common autoimmune disease in the peripheral nervous system. This study aimed to elucidate the role of IL-27 gene polymorphisms in elderly people with GBS. <b><i>Methods:<\/i><\/b> A total of 395 healthy subjects and 422 GBS patients with an average age of 63 years old were included in this study. Peripheral blood samples were collected. The 2 single-nucleotide polymorphisms (SNPs) of IL-27, namely, rs153109 and rs785575, of GBS patients were analyzed using the PCR method and compared with those of the healthy controls. The correlations of IL-27 SNPs with disease severity, disease outcome, level of anti-GM1 antibodies, and <i>Campylobacter jejuni<\/i> infection were assessed. Serum levels of IL-27 of healthy subjects and GBS patients were analyzed using enzyme-linked immunosorbent assay. <b><i>Results:<\/i><\/b> No significant differences in the frequencies of rs785575 SNPs between GBS and healthy subjects were observed. In analyzing rs153109 SNPs, the G allele was found to be more prevalent in the GBS patients (<i>p<\/i> = 0.012). More alleles show GG genotype in GBS patients (<i>p<\/i> = 0.023). The \u2212964A&#x3e;G allele has a higher prevalence in severely affected and anti-GM1-Ab-positive GBS patients. GBS patients with the rs153109 SNP showed a poor clinical outcome than those without rs153109 SNP (<i>p<\/i> = 0.012). GBS patients showed higher serum IL-27 levels than healthy subjects (<i>p<\/i> &#x3c; 0.001). The levels of IL-27 were also higher in GBS patients with genotypes of AG and GG, and those with GG genotypes showed the highest IL-27 levels. <b><i>Conclusion:<\/i><\/b> The rs153109 SNP is more prevalent in GBS patients with the GG and G allele and is associated with severer GBS, poorer clinical outcomes, and higher IL-27 levels. <\/jats:p>","DOI":"10.1159\/000519227","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T21:12:16Z","timestamp":1633381936000},"page":"854-860","source":"Crossref","is-referenced-by-count":2,"title":["Gene Polymorphisms of Interleukin-27 Correlate with the Susceptibility, Severity, and Clinical Outcomes of Elderly People with Guillain-Barr\u00e9 Syndrome"],"prefix":"10.1159","volume":"68","author":[{"given":"Huifang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guotao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.208538"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.02.003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21025-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/758639"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1258402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7754\/clin.lab.2015.150843"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05901.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2018.1545554"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-013-0753-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12209"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.02.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2015.1134665"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4512-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2180-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0235"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70130-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S80255"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.822072"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0295-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000056"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2015.1062555"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1459-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2835-5"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:23:32Z","timestamp":1745421812000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,2]]},"published-print":{"date-parts":[[2022,8,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000519227","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]}}}