{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:14:15Z","timestamp":1787606055950,"version":"build-2736575974"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Duodenal ulcers are classified into bulbar and post-bulbar ulcers. The aim of this study is to compare the long-term outcomes of patients with post-bulbar ulcer bleeding and those with bulbar ulcer bleeding. <b><i>Methods:<\/i><\/b> A total of 272 patients with hemorrhagic duodenal ulcers requiring hospitalization were included. Their medical records were retrospectively reviewed. <b><i>Results:<\/i><\/b> All patients were categorized as bulbar or post-bulbar bleeding ulcer groups. The post-bulbar ulcer group had more patients of advanced age, concurrent malignancy, diabetes mellitus, hypertension, cirrhosis, and chronic kidney disease undergoing hemodialysis. We performed long-term follow-up for an average of 2.6 years. The mortality rate during the follow-up period in the post-bulbar ulcer group was significantly higher than that in the bulbar ulcer group (<i>p<\/i> &#x3c; 0.001). The PNED score was a better predictor of 30-day mortality compared to the complete Rockall score and the Glasgow-Blatchford Score. Predictors of mortality were evaluated using a Cox proportional hazards regression model. In multivariate analysis, post-bulbar ulcer, concurrent malignancy, cirrhosis, antiplatelet\/anticoagulant use, and transfusion were significant predictors of mortality. <b><i>Conclusions:<\/i><\/b> Patients with post-bulbar ulcers have a poorer prognosis than those with bulbar ulcers. After the diagnosis of hemorrhagic post-bulbar duodenal ulcer, close follow-up is necessary. <\/jats:p>","DOI":"10.1159\/000519293","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T21:07:44Z","timestamp":1632344864000},"page":"126-132","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Outcomes in Patients with Post-Bulbar Ulcer Bleeding Compared to Bulbar Ulcer Bleeding in the Duodenum"],"prefix":"10.1159","volume":"103","author":[{"given":"Hiromi","family":"Sekiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-4470","authenticated-orcid":false,"given":"Satoshi","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-3307","authenticated-orcid":false,"given":"Takahito","family":"Takezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-5630","authenticated-orcid":false,"given":"Alan Kawarai","family":"Lefor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.687"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.316"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02816-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(51)80060-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3919\/ringe1963.40.490"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/100.1.27"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0113"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04105.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2008.11.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2003.09.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1976.tb03212.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/den.13781"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126432"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:08Z","timestamp":1745421848000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,28]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000519293","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]}}}