{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:17:20Z","timestamp":1785842240782,"version":"3.56.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> The aim of this study was to evaluate the long-term outcomes and the factors related to patient prognosis. <b><i>Materials and Methods:<\/i><\/b> We retrospectively analyzed patients treated at the Department of Gynecology, Sun Yat-sen University Cancer Center, between January 1, 1968, and December 12, 2018. <b><i>Results:<\/i><\/b> A total of 107 patients were identified. Of all patients, 79 (73.8%) presented with stage I disease, 14 (13.1%) stage II, 13 (12.2%) stage III, and 1 (0.9%) stage IV. All patients received surgery, with 70 (65.4%) undergoing fertility-sparing surgery (FS) and 37 (34.6%) nonfertility-sparing surgery (NFS). Ninety patients received postoperative chemotherapy. Nine of the 43 cases with a lymphadenectomy had metastasis (20.9%). The median follow-up time was 132 months (range, 1\u2013536 months). The overall 5-year and 10-year survival was 95.1% and 91.7%, respectively. The 10-year survival rate for stage I and II\u2013IV patients was 96.1% and 79.1%, respectively (<i>p<\/i> = 0.008). For the patients undergoing FS and NFS, the 10-year disease-free survival rate was 82.3% and 88.0%, respectively (<i>p<\/i> = 0.403). The 10-year disease-free survival rate for patients with or without lymphadenectomy was 95.1% and 78.4%, respectively (<i>p<\/i> = 0.040), and it was 92.5% and 76.0%, respectively (<i>p<\/i> = 0.041), for those with or without omentectomy. Fifteen patients relapsed, and 4 of them (26.7%) had recurrence in the lymph nodes. Eleven of the 15 relapsed patients (73.3%) had been successfully salvaged. <b><i>Limitations:<\/i><\/b> As a study of a rare disease, our analysis was limited by its small sample size and the deemed disadvantage of a retrospective study. <b><i>Conclusion:<\/i><\/b> Excellent treatment results can be achieved in dysgerminoma patients who received proper treatment. Lymphadenectomy may improve patient survival. Relapsed patients can also be successfully salvaged. <\/jats:p>","DOI":"10.1159\/000519515","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T14:06:35Z","timestamp":1639058795000},"page":"494-501","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Outcomes and Factors Related to the Prognosis of Pure Ovarian Dysgerminoma: A Retrospective Study of 107 Cases"],"prefix":"10.1159","volume":"86","author":[{"given":"Tianyun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000216004.22588.ce"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.12.024"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e4bfe9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90013-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgi011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.9.2670"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.cco.0000239891.44031.38"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.10.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903242461"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00969.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.9.2670"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6135"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:26:21Z","timestamp":1745421981000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,1,6]]},"published-print":{"date-parts":[[2022,1,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000519515","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}