{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T05:07:26Z","timestamp":1755839246987,"version":"3.40.5"},"reference-count":11,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> The aim of the study was to compare the performances of cardiothoracic diameter ratio (CTR) and middle cerebral artery peak systolic velocity (MCA-PSV) in predicting fetal hemoglobin (Hb) Bart\u2019s disease and identify the best CTR cut-off for each gestational period. <b><i>Methods:<\/i><\/b> Pregnancies at risk of fetal Hb Bart\u2019s disease (gestational ages of 12\u201336 weeks) were prospectively recruited to undergo ultrasound examination. The measurements of CTR and MCA-PSV were performed and recorded before invasive diagnosis. <b><i>Results:<\/i><\/b> During the study period (2005\u20132019), a total of 1,717 pregnancies at risk of fetal Hb Bart\u2019s disease met the inclusion criteria and were available for analysis, including 329 (19.2%) fetuses with Hb Bart\u2019s disease. The mean gestational age at the time of diagnosis was 19.30 \u00b1 5.6 weeks, ranging from 12 to 36 weeks. The overall performance of CTR <i>Z<\/i>-scores is superior to that of MCA-PSV multiple of median (MoM) values; area under curve of 0.866 versus 0.711, <i>p<\/i> value &#x3c;0.001. The diagnostic indices of CTR and MCA-PSV are increased with gestational age. Based on receiver operating characteristic curves of CTR <i>Z<\/i>-scores, the best cut-off points of CTR at 12\u201314, 15\u201317, 18\u201320, 21\u201323, and \u226524 weeks are 0.48, 0.49, 0.50, 0.51, and 0.54, respectively. The best cut-off of MCA-PSV is 1.3 MoM, giving the best performance at 21\u201323 weeks with a sensitivity of 91.8% and specificity of 85.5%. <b><i>Conclusion:<\/i><\/b> The performance of CTR is much better than MCA-PSV in predicting fetal anemia caused by Hb Bart\u2019s disease. Nevertheless, whether this can be reproduced in anemia due to other causes, like isoimmunization, is yet to be explored. <\/jats:p>","DOI":"10.1159\/000519543","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T14:06:35Z","timestamp":1639058795000},"page":"738-745","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the Performances of Middle Cerebral Artery Peak Systolic Velocity and Cardiothoracic Diameter Ratio in Predicting Fetal Anemia: Using Fetal Hemoglobin Bart\u2019s Disease as a Study Model"],"prefix":"10.1159","volume":"48","author":[{"given":"Wisit","family":"Chankhunaphas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theera","family":"Tongsong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuanglada","family":"Tongprasert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasemsri","family":"Srisupundit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchaya","family":"Luewan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-2128","authenticated-orcid":false,"given":"Kuntharee","family":"Traisrisilp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phudit","family":"Jatavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1002\/uog.6342"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.7863\/jum.2004.23.1.49"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1002\/uog.7443"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002\/uog.17555"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016\/j.bpobgyn.2019.01.001"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1002\/pd.4293"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1002\/(sici)1097-0223(199704)17:4%3c327::aid-pd67%3e3.0.co;2-n"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/s0002-9378(99)70165-1"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002\/jum.14786"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.7863\/ultra.34.2.197"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1002\/pd.5419"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:26:32Z","timestamp":1745421992000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,12,14]]},"published-print":{"date-parts":[[2021,12,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000519543","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2021]]}}}