{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:01:14Z","timestamp":1778569274030,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Carbon dioxide (pCO<sub>2<\/sub>) induces changes in the tone of cerebral vessels. The aim of the present study was to evaluate the impact of pCO<sub>2<\/sub> on cerebral regional tissue oxygen saturation (crSO<sub>2<\/sub>), cerebral fractional tissue oxygen extraction (cFTOE), and cerebral tissue oxygen extraction (cTOE), measured with near-infrared spectroscopy (NIRS), in preterm and term infants 15 min after birth. <b><i>Methods:<\/i><\/b> Post hoc analyses of secondary outcome parameters of prospective observational studies were performed. Stable preterm and term infants with cerebral NIRS monitoring (INVOS 5100C) until minute 15 after birth and a blood gas analysis, performed between minutes 14\u201318 after birth, were included. Heart rate (HR) and arterial oxygen saturation (SpO<sub>2<\/sub>) were recorded. pCO<sub>2<\/sub> was correlated with crSO<sub>2<\/sub>, cFTOE, cTOE, SpO<sub>2<\/sub>, HR, and partial pressure of oxygen (pO<sub>2<\/sub>). <b><i>Results:<\/i><\/b> Eleven preterm infants with a median (IQR) gestational age of 34.8 (32.7\u201336.1) weeks were analyzed. Mean \u00b1 SD pCO<sub>2<\/sub> was 53.5 \u00b1 4.2 mm Hg. At minute 15 after birth, crSO<sub>2<\/sub> was 82.6 (74.3\u201391.3)%, cFTOE 0.15 \u00b1 0.09, cTOE 14.6 \u00b1 8.4%, SpO<sub>2<\/sub> 97.4 \u00b1 2.1%, and HR 152 (136\u2013167) bpm. pCO<sub>2<\/sub> correlated negatively with crSO<sub>2<\/sub> (<i>p<\/i> = 0.012) and positively with cFTOE (<i>p<\/i> = 0.035) and cTOE (<i>p<\/i> = 0.037). Eighty-four term infants with a gestational age of 39.0 (38.5\u201338.9) weeks were analyzed. pCO<sub>2<\/sub> was 53.5 \u00b1 6.3 mm Hg. At minute 15 after birth, crSO<sub>2<\/sub> was 84.4 (80.8\u201385.1)%, cFTOE 0.14 \u00b1 0.08, cTOE 13.6 \u00b1 7.9%, SpO<sub>2<\/sub> 96.5 \u00b1 2.6%, and HR 155 (153\u2013163) bpm. pCO<sub>2<\/sub> did only negatively correlate with pO<sub>2<\/sub> (<i>p<\/i> = 0.034) in term infants. <b><i>Conclusion:<\/i><\/b> In preterm infants, higher pCO<sub>2<\/sub> was associated with lower crSO<sub>2<\/sub> and higher cFTOE\/cTOE. In term infants, no associations were observed. The present findings suggest that the vasodilatative effect of pCO<sub>2<\/sub> is less pronounced in preterm infants during immediate postnatal transition. <\/jats:p>","DOI":"10.1159\/000519636","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T21:00:42Z","timestamp":1635454842000},"page":"10-17","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Carbon Dioxide on Cerebral Oxygenation and Vital Parameters in Stable Preterm and Term Infants Immediately after Birth"],"prefix":"10.1159","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-3487","authenticated-orcid":false,"given":"Christina Helene","family":"Wolfsberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-7597","authenticated-orcid":false,"given":"Marlies","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-3712","authenticated-orcid":false,"given":"Bernhard","family":"Schwaberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-665X","authenticated-orcid":false,"given":"Lukas Peter","family":"Mileder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-5785","authenticated-orcid":false,"given":"Berndt","family":"Urlesberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198808000-00007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.03.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.29.5.398"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000243368"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(79)80373-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12646"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1989.tb11279.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.06.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140250051035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7477"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.07.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.053"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000346384"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000101063"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199106010-00007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11482.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300302"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000437347"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.76"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2018.05.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.110"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0925"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1956.sp005526"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/519636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:27:07Z","timestamp":1745422027000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,16]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000519636","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]}}}