{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:34:42Z","timestamp":1783625682148,"version":"3.55.0"},"reference-count":63,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; &lt;i&gt;BCR\/ABL1&lt;\/i&gt;-like acute lymphoblastic leukemia is a newly recognized high-risk subtype of ALL, characterized by the presence of genetic alterations activating kinase and cytokine receptor signaling. This subtype is associated with inferior outcomes, compared to other B-cell precursor ALL. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; The recognition of &lt;i&gt;BCR\/ABL1&lt;\/i&gt;-like ALL is challenging due to the complexity of underlying genetic alterations. Rearrangements of &lt;i&gt;CRLF2&lt;\/i&gt; are the most frequent alteration in &lt;i&gt;BCR\/ABL1&lt;\/i&gt;-like ALL and can be identified by flow cytometry. The identification of &lt;i&gt;BCR\/ABL1&lt;\/i&gt;-like ALL can be achieved with stepwise algorithms or broad-based testing. The main goal of the diagnostic analysis is to detect the underlying genetic alterations, which are critical for the diagnosis and targeted therapy. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; The aim of the manuscript is to review the available data on &lt;i&gt;BCR\/ABL1&lt;\/i&gt;-like ALL characteristics, diagnostic algorithms, and novel, molecularly targeted therapeutic options. <\/jats:p>","DOI":"10.1159\/000519782","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T22:00:57Z","timestamp":1637791257000},"page":"122-131","source":"Crossref","is-referenced-by-count":15,"title":["&lt;b&gt;&lt;i&gt;BCR\/ABL1&lt;\/i&gt;&lt;\/b&gt;-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted 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