{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:31:50Z","timestamp":1747193510458,"version":"3.40.5"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Introduction: Low-grade neuroepithelial tumors are a heterogeneous group of central nervous system tumors that are generally indolent in nature but in rare instances can progress to include leptomeningeal dissemination. Case Presentation: We present a case of a patient with a low-grade neuroepithelial tumor of indeterminate type with symptomatic leptomeningeal dissemination despite 3 chemotherapy regimens and radiotherapy. Somatic targetable mutation testing showed an FGFR1_TACC1 fusion. Therapy with pazopanib\/topotecan was initiated, and disease stabilization was achieved. He received pazopanib\/topotecan for a total of 2 years and is now &gt;2 years from completion of treatment and continues to do well with no evidence of disease. Discussion: This case highlights the utility of targetable mutation testing in therapeutic decision-making and the novel use of systemic pazopanib\/topotecan therapy for refractory low-grade neuroepithelial tumor within the context of this clinical situation and specific mutation profile. <\/jats:p>","DOI":"10.1159\/000519889","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T22:00:43Z","timestamp":1636408843000},"page":"63-68","source":"Crossref","is-referenced-by-count":1,"title":["Leptomeningeal Dissemination of Low-Grade Neuroepithelial Tumor with FGFR1_TACC1 Fusion with Clinical and Radiographic Response to Pazopanib and Topotecan"],"prefix":"10.1159","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-4577","authenticated-orcid":false,"given":"Alexander T.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"Skrypek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Tabori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5832","authenticated-orcid":false,"given":"Kris Ann P.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1177\/0883073809342005"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1093\/neuonc\/noq092"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1227\/NEU.0b013e318214a66e"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1038\/bjc.2015.257"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1093\/neuonc\/4.4.253"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1002\/pbc.25731"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1002\/pbc.23006"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.3171\/jns.1997.86.5.0747"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1200\/JCO.2011.36.6054"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1200\/jco.2011.29.15_suppl.9524"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1093\/neuonc\/now240"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1038\/ng.2611"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016\/j.ccell.2020.03.011"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1186\/s40478-020-00898-6"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016\/j.critrevonc.2010.02.012"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016\/j.eururo.2015.02.023"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.6004\/jnccn.2017.7030"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1007\/BF00685936"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1007\/BF00688317"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1158\/1078-0432.CCR-11-0078"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1200\/JCO.2004.10.103"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1200\/JCO.1994.12.3.539"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1002\/cncr.20168"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1093\/hmg\/10.26.3001"}],"container-title":["Pediatric Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pne\/article-pdf\/57\/1\/63\/3899492\/000519889.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/pne\/article-pdf\/57\/1\/63\/3899492\/000519889.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:29:36Z","timestamp":1745422176000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000519889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,28]]},"published-print":{"date-parts":[[2022,2,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000519889","archive":["Portico"],"relation":{},"ISSN":["1016-2291","1423-0305"],"issn-type":[{"type":"print","value":"1016-2291"},{"type":"electronic","value":"1423-0305"}],"subject":[],"published":{"date-parts":[[2021,11,8]]}}}