{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:24Z","timestamp":1745468664594,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Purpose:<\/i><\/b> This study aimed to analyze neuroendocrine neoplasm (NEN) bone metastasis (BM) and gallium-68 (<sup>68<\/sup>Ga)-DOTA-TATE performance and to explore their correlation with the immunohistochemical proliferation index (Ki-67). <b><i>Procedures:<\/i><\/b> A total of 112 patients with BMs were screened from 1082 NEN patients who underwent [<sup>68<\/sup>Ga]Ga-DOTA-TATE imaging. All patients had pathological results, and BMs were affirmed by clinical\/imaging follow-up and\/or histopathology. The maximum standard uptake value (SUVmax) ratio of BM to normal bone determined for each patient was used in the final analysis. <b><i>Results:<\/i><\/b> The incidence rate of BMs in NENs was 10.35%. BMs occurred in the spine (75%), pelvis (72.3%), ribs (58%), clavicles and scapulae (41.1%), limbs (37.5%), and skull (28.6%). Most cases were associated with liver metastases (70.5%) and lymph node metastases (65.2%) simultaneously. The SUVmax ratio of G3b (median ratio = 3.77, Ki-67 &#x3e;55%) was significantly lower than that of G1 (11.43, Ki-67 \u22642%) and G2a (11.15, 3% \u2264 Ki-67 \u226410%) separately (<i>p<\/i> &#x3c; 0.05), while no differences were found for G2b (8.5, 11% \u2264 Ki-67 \u226455%) and G3a (6.64, Ki-67 &#x3e;55%) groups. In the total patients, there was a significant negative correlation between the SUVmax ratio of BMs to normal bone and Ki-67 (<i>r<\/i> = \u22120.267, <i>p<\/i> &#x3c; 0.01). According to the changes in bone density on CT scans, the cases were divided into 4 groups: osteogenesis, osteolysis, no change, and a mixed group (median Ki-67: 6.5%, 15%, 12%, and 22.5%). The Ki-67 values were significantly different between the osteogenesis group and the other groups (<i>p<\/i> &#x3c; 0.05). <b><i>Conclusion:<\/i><\/b> BM is present in 10.35% of NEN patients and most have simultaneous liver and\/or lymph node metastases. The occurrence of osteogenesis indicates relatively good differentiation, and there is a negative correlation between SUVmax ratio of BMs and NEN proliferation. <\/jats:p>","DOI":"10.1159\/000520191","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T21:13:42Z","timestamp":1634246022000},"page":"666-672","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between NEN Bone Metastasis Performance and Tumor Proliferation: 112 Cases of [<sup>68<\/sup>Ga]Ga-DOTA-TATE Result Analysis"],"prefix":"10.1159","volume":"112","author":[{"given":"Qing","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhen","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changzhi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1159\/000080731"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1002\/cncr.29099"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1093\/annonc\/mdq022"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002\/ijc.30400"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1097\/MPA.0000000000000267"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.21037\/jtd.2018.06.78"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1159\/000335597"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1007\/s11307-019-01328-3"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1007\/s00259-009-1349-9"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.3390\/cancers10060182"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1155\/2018\/2340389"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1097\/RLU.0b013e31823361f7"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.2967\/jnumed.115.162719"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:27:10Z","timestamp":1745422030000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,14]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000520191","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"type":"print","value":"0028-3835"},{"type":"electronic","value":"1423-0194"}],"subject":[],"published":{"date-parts":[[2021,10,14]]}}}