{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:59:07Z","timestamp":1790675947811,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Body mass index (BMI) is often elevated at type 2 diabetes (T2D) diagnosis. Using latent class trajectory modelling (LCTM) of BMI, we examined whether weight loss after diagnosis influenced cancer incidence and all-cause mortality. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From 1995 to 2010, we identified 7,708 patients with T2D from the Salford Integrated Record database (UK) and linked to the cancer registry for information on obesity-related cancer (ORC), non-ORC; and all-cause mortality. Repeated BMIs were used to construct sex-specific latent class trajectories. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four sex-specific BMI classes were identified; stable-overweight, stable-obese, obese-slightly-decreasing, and obese-steeply-decreasing; comprising 41%, 45%, 13%, and 1% of women, and 45%, 37%, 17%, and 1% of men, respectively. In women, the stable-obese class had similar ORC risks as the obese-slightly-decreasing class, whereas the stable-overweight class had lower risks. In men, the obese-slightly-decreasing class had higher risks of ORC (HR = 1.86, 95% CI: 1.05\u20133.32) than the stable-obese class, while the stable-overweight class had similar risks No associations were observed for non-ORC. Compared to the stable-obese class, women (HR = 1.60, 95% CI: 0.99\u20132.58) and men (HR = 2.37, 95% CI: 1.66\u20133.39) in the obese-slightly-decreasing class had elevated mortality. No associations were observed for the stable-overweight classes. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Patients who lost weight after T2D diagnosis had higher risks for ORC (in men) and higher all-cause mortality (both genders) than patients with stable obesity.<\/jats:p>","DOI":"10.1159\/000520200","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T17:00:35Z","timestamp":1639414835000},"page":"150-159","source":"Crossref","is-referenced-by-count":7,"title":["Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study"],"prefix":"10.1159","volume":"15","author":[{"given":"Britt W.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-6676","authenticated-orcid":false,"given":"Nophar","family":"Geifman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-6615","authenticated-orcid":false,"given":"Jennifer L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellena","family":"Badrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Renehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxm008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1606602"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2016-000369"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105868"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.02.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010836"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.05.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-018-0042-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5554"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.07.084"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.29"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw225"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-013-2399-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.1917"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0328-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4417"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/srep43521"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012075"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0441-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2018-001514"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:27:13Z","timestamp":1745407633000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,3,22]]},"published-print":{"date-parts":[[2022,3,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000520200","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.17174894","asserted-by":"subject"}]},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,13]]}}}