{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:33:11Z","timestamp":1780317191099,"version":"3.54.1"},"reference-count":32,"publisher":"S. Karger AG","issue":"7-8","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Adult women with Turner syndrome (TS) have a high prevalence of diabetes and \u03b2-cell dysfunction that increases morbidity and mortality, but it is unknown if there is \u03b2-cell dysfunction present in youth with TS. This study aimed to determine the prevalence of \u03b2-cell dysfunction in youth with TS and the impact of traditional therapies on insulin sensitivity (SI) and insulin secretion. <b><i>Methods:<\/i><\/b> Cross-sectional, observational study recruited 60 girls with TS and 60 healthy controls (HC) matched on pubertal status. Each subject had a history, physical exam, and oral glucose tolerance test (OGTT). Oral glucose and c-peptide minimal modeling was used to determine \u03b2-cell function. <b><i>Results:<\/i><\/b> Twenty-one TS girls (35%) met criteria for prediabetes. Impaired fasting glucose was present in 18% of girls with TS and 3% HC (<i>p<\/i> value = 0.02). Impaired glucose tolerance was present in 23% of TS girls and 0% HC (<i>p<\/i> value &#x3c;0.001). The hemoglobin A1c was not different between TS and HC (median 5%, <i>p<\/i> = 0.42). Youth with TS had significant reductions in SI, \u03b2-cell responsivity (\u03a6), and disposition index (DI) compared to HC. These differences remained significant when controlling for body mass index <i>z<\/i>-score (<i>p<\/i> values: 0.0006, 0.002, &#x3c;0.0001 for SI, \u03a6 total, DI, respectively). <b><i>Conclusions:<\/i><\/b> \u03b2-Cell dysfunction is present in youth with TS compared to controls. The presence of both reduced insulin secretion and SI suggest a unique TS-related glycemic phenotype. Based on the data from this study, we strongly suggest that providers employ serial OGTT to screen for glucose abnormalities in TS youth. <\/jats:p>","DOI":"10.1159\/000520233","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T21:00:33Z","timestamp":1634331633000},"page":"297-306","source":"Crossref","is-referenced-by-count":12,"title":["Increased Prevalence of Beta-Cell Dysfunction despite Normal HbA1c in Youth and Young Adults with Turner 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