{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T01:54:00Z","timestamp":1783216440348,"version":"3.54.6"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present 2 such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31(\u2212) and D2-40\/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid, and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor cells in a sheet form, extensively throughout the dermis. Angiosarcoma was preferred based on immunohistochemistry: CD31(+), CD34(+), and D2-40(\u2212). The patient was treated with electron beam therapy and chemotherapy and died after 13 months. It would be difficult for an ophthalmologist to suspect such a rare neoplasm only from swelling of the eyelids. However, angiosarcoma should be considered if the swelling spreads steadily from a head rash with a nodule or ulcer nearby. <\/jats:p>","DOI":"10.1159\/000520293","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T21:01:16Z","timestamp":1634850076000},"page":"16-21","source":"Crossref","is-referenced-by-count":1,"title":["Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling"],"prefix":"10.1159","volume":"8","author":[{"given":"Shinzo","family":"Sakisaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Imayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Zeze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Yamana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh-Hei","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/321896"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.3584"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.07.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197909)44:3%3c1106::aid-cncr2820440345%3e3.0.co;2-c"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870301)59:5%3c1046::aid-cncr2820590533%3e3.0.co;2-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000227544.01779.52"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-009-0147-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710601110"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700653"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1995.tb01650.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(98)00054-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199911000-00019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.06.083"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11667"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318271295a"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.05.352"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202629"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11%3c2400::AID-CNCR32%3e3.0.CO;2-Z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11667"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/31655219"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.3146"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/520293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:28:00Z","timestamp":1745422080000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000520293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,15]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000520293","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]}}}