{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:51:41Z","timestamp":1776588701318,"version":"3.51.2"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Introduction:<\/i><\/b> Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative effects of a boron-based gel on several different clinical outcomes (dermatitis, erythema, dry desquamation, and moist desquamation) after 25 radiotherapy sessions. <b><i>Methods:<\/i><\/b> This research used a double-blind parallel-group design with a placebo control (<i>n<\/i> = 76) and randomized group (<i>n<\/i> = 181), with all participants being between 18 and 75 years old. Fifteen minutes before each radiotherapy, participants in the intervention group were given a gel containing 3% sodium pentaborate pentahydrate, while those in the placebo group received a gel with no chemical substance. Dermatitis, erythema, dry desquamation, and moist desquamation were compared between the 2 groups. <b><i>Results:<\/i><\/b> At baseline, there were no significant differences between the groups (<i>p<\/i> &#x3e; 0.05), except for body mass index. After 14 days of treatment, dermatitis (98.7% vs. 9.9%; <i>p<\/i> &#x3c; 0.001), erythema (96.1% vs. 12.2%; <i>p<\/i> &#x3c; 0.001), dry desquamation (50% vs. 3.9%; <i>p<\/i> &#x3c; 0.001), and moist desquamation (18.4% vs. 0.6%; <i>p<\/i> &#x3c; 0.001) were much more common in the placebo group than the intervention group. To prevent dermatitis, erythema, dry desquamation, and moist desquamation in 1 patient, on average, 1.1 (95% confidence interval [CI]: 1.1\u20131.2), 1.2 (95% CI: 1.1\u20131.3), 2.2 (95% CI: 1.7\u20132.9), and 5.6 (95% CI: 3.8\u201311.0) patients need to be treated, respectively. <b><i>Conclusion:<\/i><\/b> The boron-based gel has a significant preventive effect on several categories of RD which might be used by clinicians in breast cancer. <\/jats:p>","DOI":"10.1159\/000520363","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:00:39Z","timestamp":1641247239000},"page":"197-204","source":"Crossref","is-referenced-by-count":7,"title":["The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical 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